ArticleMaterials (Basel, Switzerland)2026
Strengthened Anti-Inflammatory Potential of a Purified Antimicrobial Peptide Extract in Leukocyte-Biomaterial Interactions.
Article in Materials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excessive inflammation following implant insertion may impair early healing and predispose to postoperative complications. Since neutrophils constitute the predominant leukocyte population during the initial inflammatory phase, and monocytes subsequently orchestrate tissue resolution and repair, understanding their direct response to biomaterials and bioactive compounds is essential. In the present study, we evaluated the effect of purified bioactive extract combined with biomaterial on neutrophil and monocyte activity in vitro, comparing their modulatory potential with that of non-purified extract. Porcine neutrophils and monocytes were cultured in contact with hydroxyapatite (HA) mixed with purified fractions obtained through sequential chromatographic isolation. Cellular responses were assessed by measuring enzyme release and reactive oxygen/nitrogen species (ROS/RNS) generation. Neutrophils exposed to HA alone displayed a pronounced oxidative response, confirming strong activation. Purified extracts, however, significantly reduced ROS/RNS production (NO: 2.71 ± 0.07 µM vs. HA-only group 5.72 ± 0.10 µM,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.