Evidence map›Paper›PMID 42882522›Full record

ArticleCells2026

Olfactory Swab-Derived Human Neuroepithelium Cell Culture as a Novel Model to Study Neurodegeneration-Related Proteins.

Francesco Silvestri, Erika Bronzato, Ilaria Scambi, Valerio Arietti, Luca Sacchetto, Raffaella Mariotti, Gianluigi Zanusso, Matilde Bongianni, Ermanna Turano

Abstract read
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In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesco SilvestriDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0009-0001-8365-1612
Erika BronzatoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Ilaria ScambiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-7678-6359
Valerio AriettiDepartment of Surgery, Dentistry, Paediatrics and Gynaecology, Otolaryngology Section, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-0700-2792
Luca SacchettoDepartment of Surgery, Dentistry, Paediatrics and Gynaecology, Otolaryngology Section, University of Verona, 37134 Verona, Italy.
Raffaella MariottiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Gianluigi ZanussoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-5199-6264
Matilde BongianniDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-6009-5502
Ermanna TuranoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-0760-1787

Funding

AriSLA - Fondazione Italiana di Ricerca per la SLA Bando 2024 ZANUSSO_ARISLA_DEFINEALSMinistry of Universities and Research National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006) - A Multiscale inte-grated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022).
6 · The paper itself

Abstract

The olfactory neuroepithelium (ON) collected with nasal swabs (NS) is a valuable source for studying brain processes in physiological and pathological conditions, due to its anatomical proximity to the brain and heterogeneous neural cell population. In this proof-of-concept study, we developed a protocol for co-culturing distinct cellular populations from ON, establishing a human olfactory neuroepithelium cell culture (hON) model from healthy individuals (HIs) without differentiation factors. We characterized the cellular composition of ON samples at harvesting, identifying sustentacular cells (Pan-CK

Indexed as

Cell Culture TechniquesModels, BiologicalNeurodegenerative DiseasesNeuroepithelial CellsOlfactory Mucosaalpha-SynucleinCells, CulturedFemaleHumansMaleMiddle AgedNeuronstau Proteinsalpha-Synucleintau Proteinscell culturesnasal culturesneurodegenerationolfactory neuroepithelium

Identifiers

PMID42882522
PMCPMC13664212

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.