Evidence map›Paper›PMID 42882517›Full record

ArticleCells2026

Correlation Between Gut Microbiota Shifts, Lipopolysaccharide Levels, and Neuroinflammatory Responses Following Ischemic Stroke.

Kemin Li, Wancong Ding, Shuang Wang, Gaowei Pan, Shengxiang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kemin LiSchool of Food Science and Engineering, Xinjiang Institute of Technology, No. 1 Xuefu Road West, Aksu 843100, China.
Wancong DingGansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, China.
Shuang WangGansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, China.
Gaowei PanGansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, China.
Shengxiang ZhangGansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, China.ORCID 0000-0001-6524-9673

Funding

Gansu Academy of Sciences No. 22JR5RA437Lanzhou University No. cxcy202005
6 · The paper itself

Abstract

backgroundThe microbiota-gut-brain axis (MGBA) is increasingly recognized as a contributor to ischemic stroke pathophysiology, yet the relationship between gut microbial changes and neuroinflammation remains incompletely understood. This study aimed to investigate whether shifts in gut microbiota are associated with concurrent changes in lipopolysaccharide (LPS) levels and neuroinflammatory responses following ischemic stroke.

methodsUsing a photothrombotic mouse model, we measured LPS in the gut, serum, and brain via ELISA and immunohistochemistry. Gentamycin was administered to deplete gut bacteria and assess its effects on LPS and stroke recovery. Upon TLR4 inhibition with TAK-242, microglial polarization and inflammatory cytokines were evaluated, and dose-dependent LPS supplementation was performed.

resultsIschemic stroke was accompanied by elevated LPS levels in the gut, circulation, and brain, paralleling

conclusionsThese findings reveal a spatial correlation between gut microbial shifts, circulating LPS, and cerebral LPS immunoreactivity, suggesting LPS may serve as a correlative marker of gut-brain interactions following ischemic stroke.

Indexed as

Gastrointestinal MicrobiomeIschemic StrokeLipopolysaccharidesNeuroinflammatory DiseasesAnimalsBrainCytokinesDisease Models, AnimalMaleMiceMice, Inbred C57BLMicrogliaToll-Like Receptor 4CytokinesLipopolysaccharidesToll-Like Receptor 4ischemic strokelipopolysaccharide (LPS)microbiota–gut–brain axis (MGBA)microglial polarizationneuroinflammatory responses

Identifiers

PMID42882517
PMCPMC13664211

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.