Spatiotemporal Redox Regulation of Cell-Cycle Progression: Dynamic Functions of Cellular Redox Regulatory Proteins.

Aerobic life revolves around the enigmatic role of oxygen, which sustains the life cycle by supporting energy production while simultaneously threatening its existence through the generation of reactive oxygen species (ROS). Intriguingly, ROS are not merely by-products of energy generation; cells actively invest in their production through dedicated pro-oxidant systems. A long-standing perception in the scientific community has been that cellular antioxidant systems primarily evolved as terminators of ROS to protect against oxidative damage. It appears paradoxical, however, that the complex, multilayered antioxidant defense built by cells may actually relay, propagate, and buffer ROS in a spatiotemporal manner rather than simply scavenge them. Perpetuation of life essentially depends upon the cell cycle, one of the most orderly and tightly regulated cellular events. While several elegant reviews have highlighted that cell-cycle regulatory proteins are subject to redox modifications and that changes in cellular redox state influence cell-cycle fate, the converse relationship has received relatively less attention. Proteins regulating cellular antioxidant defense themselves undergo cell-cycle phase-specific changes in their abundance, activity, and localization. There therefore appears to be a coordinated and integrated redox network operating during cell-cycle progression. Here, we examine this relationship from a protein-centric perspective, focusing on MnSOD/H