Evidence map›Paper›PMID 42882508›Full record

ArticleCells2026

PARP1 Deficiency Attenuates Cisplatin Nephrotoxicity and Renal COX-2/PGE2 Response.

Theophilus Bhatti, Jia-Bin Yu, Ji-Yeong Bae, Jinu Kim

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Theophilus BhattiInterdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea.ORCID 0000-0003-4914-0656
Jia-Bin YuDepartment of Anatomy, College of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
Ji-Yeong BaeInterdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea.ORCID 0000-0003-0543-9138
Jinu KimInterdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea.ORCID 0000-0002-1313-4791

Funding

Jeju National University 2025 scientific promotion program
6 · The paper itself

Abstract

Cisplatin is a widely used chemotherapeutic agent whose clinical utility is limited by nephrotoxicity, characterized by tubular injury and renal inflammation. Poly(ADP-ribose) polymerase 1 (PARP1) contributes to cisplatin-induced kidney injury and inflammatory signaling, but the downstream inflammatory pathways involved remain incompletely defined. Here, we investigated whether PARP1 modulates the renal cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) response during cisplatin-induced acute kidney injury (AKI). Female wild-type and

Indexed as

Acute Kidney InjuryCisplatinCyclooxygenase 2DinoprostoneKidneyPoly (ADP-Ribose) Polymerase-1AnimalsFemaleInflammationMaleMiceMice, Inbred C57BLMice, KnockoutNF-kappa BSignal TransductionCisplatinCyclooxygenase 2DinoprostoneNF-kappa BParp1 protein, mousePoly (ADP-Ribose) Polymerase-1Ptgs2 protein, mouseacute kidney injurychemokinecisplatincyclooxygenase-2inflammationnephrotoxicityPARP1prostaglandin E2Ptgs2tubular injury

Identifiers

PMID42882508
PMCPMC13664194

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.