ArticleCells2026
Brown Adipocyte BMAL1 Deficiency Is Associated with PVAT Remodeling and Increased Atherosclerosis.
Ruiyan Xu, Zhenguo Wang, Wenjuan Mu, Juan Zhong, Yao Liu, Yanhong Guo, Jifeng Zhang, Y Eugene Chen, Guohua Li, Lin Chang
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Ruiyan XuKey Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Department of Pathophysiology, Hengyang Medical School, University of South China, Hengyang 421001, China.ORCID 0000-0002-4992-8112 Zhenguo WangDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48105, USA.
Wenjuan MuDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48105, USA.
Juan ZhongDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48105, USA.
Yao LiuKey Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Department of Pathophysiology, Hengyang Medical School, University of South China, Hengyang 421001, China.ORCID 0000-0003-3063-2167 Yanhong GuoDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48105, USA.ORCID 0000-0002-3334-9159 Jifeng ZhangDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48105, USA.
Y Eugene ChenDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48105, USA.
Guohua LiKey Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Department of Pathophysiology, Hengyang Medical School, University of South China, Hengyang 421001, China.
Lin ChangDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48105, USA.ORCID 0000-0002-5621-8426 Funding
American Heart Association 0.58275/AHA.25CDA1446568.pc.gr.229614American Heart Association No. 26POST1562389Department of Science and Technology of Hunan Province No. 2025JJ70115University of Michigan
6 · The paper itselfAbstract
Perivascular adipose tissue (PVAT) is increasingly recognized as an active vascular regulator that influences inflammation, metabolism, and atherosclerotic progression. In healthy vessels, PVAT displays brown adipose-like features and contributes to vascular protection, whereas PVAT dysfunction is associated with adipose whitening, inflammatory activation, and enhanced plaque formation. Circadian clock genes are major regulators of tissue metabolism, yet their role in PVAT biology and atherosclerosis remains incompletely understood. Here, we investigated the function of the core circadian factor BMAL1 in brown adipocytes and PVAT using a brown adipocyte-specific BMAL1 knockout model (
Indexed as
Adipocytes, BrownARNTL Transcription FactorsAtherosclerosisAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutARNTL Transcription FactorsBmal1 protein, mouseatherosclerosisBMAL1ChREBPPVAT
Identifiers
PMID42882489
PMCPMC13664416
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