Evidence map›Paper›PMID 42882487›Full record

ArticleCells2026

Mitofusin Activation Delays Aging in

Jochen Weigele, Lihong Zhang, Jiajia Li, Elisabeth Roider, Caroline E Walton, Gerald W Dorn

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jochen WeigeleDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA.
Lihong ZhangDepartment of Internal Medicine, Center for Pharmacogenomics, Washington University in St. Louis, Saint Louis, MO 63110, USA.
Jiajia LiDepartment of Internal Medicine, Center for Pharmacogenomics, Washington University in St. Louis, Saint Louis, MO 63110, USA.
Elisabeth RoiderDepartment of Dermatology, University Hospital of Basel, 4031 Basel, Switzerland.
Caroline E WaltonDepartment of Internal Medicine, Center for Pharmacogenomics, Washington University in St. Louis, Saint Louis, MO 63110, USA.
Gerald W DornDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
THE MITOCHONDRIAL DYNAMISM/FITNESS/BIOGENESIS INTERACTOME IN CARDIAC DISEASER35HL135736 · NHLBI · WASHINGTON UNIVERSITY · PI DORN, GERALD W. · 2017 to 2023
$6.4M
Mitofusin 2 as a Nodal Regulator of Mitochondrial Function in CardiomyopathyR35HL171080 · NHLBI · WASHINGTON UNIVERSITY · PI Gerald W. Dorn · 2024 to 2026
$3.2M
NHLBI NIH HHS R35 HL135736NHLBI NIH HHS R35 HL171080NIH HHS P40 OD010440
6 · The paper itself

Abstract

Age-linked tissue dysfunction is associated with mitochondrial degeneration manifested as organelle fragmentation and respiratory dysfunction. Efforts to mitigate downstream consequences of mitochondrial degeneration, as with ROS scavengers, have not translated to the human condition. We posit that intrinsic fusion-mediated mechanisms for mitochondrial protection modulate aspects of aging linked to mitochondrial abnormalities. In

Indexed as

AgingCaenorhabditis elegansCaenorhabditis elegans ProteinsGTP PhosphohydrolasesAnimalsLongevityMitochondriaMitochondrial DynamicsOxidative StressCaenorhabditis elegans ProteinsFZO-1 protein, C elegansGTP Phosphohydrolaseshealthspanlifespanmitochondrial fusion

Identifiers

PMID42882487
PMCPMC13664537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.