Evidence map›Paper›PMID 42882456›Full record

SynthesisCells2026

Meta-Analysis of Porcine Beige Adipogenesis with Cross-Species CD137-CD137L Molecular Docking: Potential Implications for Pig-to-Human Xenotransplantation.

Zhenhua Guo, Liang Wang, Xinmiao He, Shuo Yang, Hong Ma, Bo Fu, Fang Wang, Di Liu, Dongjie Zhang

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenhua GuoInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.ORCID 0000-0003-0592-5988
Liang WangInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Xinmiao HeInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Shuo YangInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Hong MaInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Bo FuInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Fang WangInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Di LiuInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Dongjie ZhangInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.

Funding

China Agriculture Research System of MOF and MARA CARS-34National Natural Science Foundation of China 32673665Natural Science Foundation of Heilongjiang Province TD2024C002Science and Technology Innovation Project of Heilongjiang Academy of Agriculture Sciences CX23ZD06
6 · The paper itself

Abstract

Breakthroughs in gene-editing technologies have brought pig-to-human xenotransplantation to the clinical forefront. Nevertheless, the micro-scale impacts of the complex pathophysiological milieu within recipients on grafts have long been overlooked by the academic community. Focusing on stromal vascular fraction (SVF) cells and preadipocytes widely present in donor organs, this study explores the potential mechanism underlying beige adipogenesis induced by post-operative anti-inflammatory drugs (e.g., dexamethasone) and surgical stress (norepinephrine), as well as its possible relationship with host immune system activation. The literature search and study-selection reporting were informed by PRISMA 2020. Five information sources were searched, and nine relevant studies on experimentally induced porcine adipose beiging, predominantly in vitro, were included in marker-specific meta-analyses. The meta-analysis showed a higher pooled expression of

Indexed as

AdipogenesisMolecular Docking SimulationTransplantation, HeterologousTumor Necrosis Factor Receptor Superfamily, Member 9AnimalsHumansSwineTumor Necrosis Factor Receptor Superfamily, Member 9beige adipocyte tissueCD137fatpigUCP1

Identifiers

PMID42882456
PMCPMC13664533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.