Evidence map›Paper›PMID 42882428›Full record

ArticleCells2026

Study of the Expression of Integrins in Smooth Myocytes of the Gastrointestinal Organs After Space Flight.

Tatyana Samoilenko, Viktoria Shishkina, Svetlana Zolotaryova, Andrey Kostin, Alexander Alekhnovich, Artem Volodkin, Anna Kireeva, Igor Buchwalow, Markus Tiemann, Dmitrii Atiakshin

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tatyana SamoilenkoFederal State Budget Educational Institution of Higher Education «N.N. Burdenko Voronezh State Medical University», Ministry of Healthcare of the Russian Federation, 394036 Voronezh, Russia.ORCID 0000-0001-9990-535X
Viktoria ShishkinaFederal State Budget Educational Institution of Higher Education «N.N. Burdenko Voronezh State Medical University», Ministry of Healthcare of the Russian Federation, 394036 Voronezh, Russia.ORCID 0000-0001-9185-4578
Svetlana ZolotaryovaFederal State Budget Educational Institution of Higher Education «N.N. Burdenko Voronezh State Medical University», Ministry of Healthcare of the Russian Federation, 394036 Voronezh, Russia.ORCID 0000-0002-2136-8272
Andrey KostinThe Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, RUDN University, 117198 Moscow, Russia.
Alexander AlekhnovichThe Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, RUDN University, 117198 Moscow, Russia.
Artem VolodkinThe Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, RUDN University, 117198 Moscow, Russia.
Anna KireevaThe Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, RUDN University, 117198 Moscow, Russia.ORCID 0000-0001-8134-0899
Igor BuchwalowThe Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, RUDN University, 117198 Moscow, Russia.ORCID 0000-0003-1142-7483
Markus TiemannInstitute for Hematopathology, Fangdieckstr, 75a, 22547 Hamburg, Germany.ORCID 0000-0003-4060-8355
Dmitrii AtiakshinFederal State Budget Educational Institution of Higher Education «N.N. Burdenko Voronezh State Medical University», Ministry of Healthcare of the Russian Federation, 394036 Voronezh, Russia.ORCID 0000-0002-8347-4556

Funding

RUDN University 210506-0-000
6 · The paper itself

Abstract

Spaceflight has crucial effects on living organisms, primarily due to weightlessness, which causes essential morphofunctional changes in the tissues of almost all body systems. Smooth muscle tissue is one of the main system-forming components of the gastrointestinal tract, which makes its study particularly relevant to space gastroenterology. Integrins are cell adhesion receptors expressed in practically all cell types, including smooth muscle cells. By mediating interactions with the extracellular matrix and intercellular signaling, smooth muscle cell integrins actively participate in adaptation to microgravity conditions. However, this aspect of smooth muscle tissue function has not been addressed in space gastroenterology until now. The aim of the study was to investigate the expressions of integrins alpha-5, alpha-2, and alpha-1 expression in smooth myocytes of the gastric and jejunal muscular layer in Mongolian gerbils (

Indexed as

Gastrointestinal TractIntegrinsMyocytes, Smooth MuscleSpace FlightAnimalsGerbillinaeJejunumMaleWeightlessnessIntegrinsgastrointestinal tractintegrin alpha-5jejunumsmooth muscle tissuesmooth myocytespaceflightstomach

Identifiers

PMID42882428
PMCPMC13663986

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.