Evidence map›Paper›PMID 42882420›Full record

ArticleCells2026

Germline Genomic and DNA Methylation Differences Between MGUS and Multiple Myeloma Among Patients of African Ancestry.

Jing Han, Sophie Hongfei Liu, Shahram Arsang-Jang, Zongli Xu, Kelly E Rentscher, Angela J Mathison, Mike Tschannen, Fumou Sun, Paul L Auer, Sarah Kerns and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jing HanDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 5860, Milwaukee, WI 53226, USA.
Sophie Hongfei LiuMellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0009-0000-3604-3238
Shahram Arsang-JangDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 5860, Milwaukee, WI 53226, USA.
Zongli XuBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, NC 27709, USA.ORCID 0000-0002-9034-8902
Kelly E RentscherDepartment of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Angela J MathisonMellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-6763-2710
Mike TschannenMellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Fumou SunDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 5860, Milwaukee, WI 53226, USA.
Paul L AuerDivision of Biostatistics, Data Science Institute, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Sarah KernsMedical College of Wisconsin Cancer Center, Milwaukee, WI 53226, USA.ORCID 0000-0002-6503-0011
Parameswaran HariDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 5860, Milwaukee, WI 53226, USA.
Binod DhakalDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 5860, Milwaukee, WI 53226, USA.
Siegfried JanzDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 5860, Milwaukee, WI 53226, USA.
Victor X JinMellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-8765-3471
Raul UrrutiaMellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Anita D'souzaDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 5860, Milwaukee, WI 53226, USA.
Jing DongDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 5860, Milwaukee, WI 53226, USA.ORCID 0000-0001-9856-5963

Funding

Prognostic implications of mitochondrial inheritance in myelodysplastic syndromes after stem-cell transplantationK01HL164972 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Jing Dong · 2023 to 2026
$697k
Accelerated biological and phenotypic aging in hematopoietic cell transplant survivors: Social support as a protective factorK01AG065485 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RENTSCHER, KELLY E · 2020 to 2024
$600k
American Cancer Society IRG-19-138-34Blood Cancer United Translational Research Program 6701-25National Heart Lung and Blood Institute K01HL164972NHLBI NIH HHS K01 HL164972NIA NIH HHS K01 AG065485NIA NIH HHS K01AG065485Paula and Rodger Riney Foundation
6 · The paper itself

Abstract

Individuals of African ancestry (AA) have approximately twofold higher risk of multiple myeloma (MM) than individuals of European ancestry, yet the molecular determinants between monoclonal gammopathy of undetermined significance (MGUS) and MM remain poorly defined. We performed whole-exome sequencing (WES) and genome-wide DNA methylation profiling in 28 AA patients with MM and 28 frequency-matched AA patients with MGUS without documented progression. After quality control, the WES analysis included 28 patients with MGUS and 27 with MM, while the DNA methylation analysis included 27 patients with MGUS and 26 with MM. Whole-exome sequencing identified differences in observed germline variant distributions, with qualifying

Indexed as

Black PeopleDNA MethylationGerm CellsGerm-Line MutationMonoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaAgedFemaleHumansMaleMiddle Agedmethylationmonoclonal gammopathy of undetermined significancemultiple myelomawhole-exome sequencing

Identifiers

PMID42882420
PMCPMC13663980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.