ArticleCells2026
NooQ5 Supplementation Promotes Myogenic Differentiation in C2C12 Cells Under Chemical and Oxidative Stress Models.
Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Dietary nucleotides offer metabolic and antioxidant benefits, yet their direct impact on skeletal myogenesis and structural recovery remains to be fully elucidated. This study evaluated the comparative efficacy of the nucleotide formulation NooQ5 against creatine monohydrate in modulating differentiation, cellular stress, and regeneration in C2C12 myoblasts. Initial screening established a dose-dependent response, where 500 mg/L promoted cell proliferation, whereas 100 mg/L improved cell differentiation, without compromising cell viability. In uninjured cells, NooQ5 significantly accelerated early mTOR and S6 ribosomal protein phosphorylation within 1 h relative to creatine, driving downstream desmin accumulation by 72 h. Under H
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