SLC25A4

Yiting Qian, Linying Lai, Yu Zhang, Yan Meng, Ziping Song, Baoyuan Huang, Guisheng Song, Bo Sun, Wenzhuo Yang

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiting Qian *Department of Gastroenterology and Hepatology, Institute of Digestive Disease, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0003-4877-0138

Linying Lai *Department of Gastroenterology and Hepatology, Institute of Digestive Disease, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0001-5464-9823

Yu Zhang *Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0009-0000-0225-4002

Yan MengSchool of Pharmacy, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.ORCID https://orcid.org/0000-0003-3009-6800

Ziping SongDepartment of Gastroenterology and Hepatology, Institute of Digestive Disease, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0009-0005-1250-7575

Baoyuan HuangDepartment of Gastroenterology and Hepatology, Institute of Digestive Disease, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0009-0001-8587-9303

Guisheng SongDepartment of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-7309-4170

Bo SunDepartment of Gastroenterology and Hepatology, Institute of Digestive Disease, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0001-6808-9943

Wenzhuo YangDepartment of Gastroenterology and Hepatology, Institute of Digestive Disease, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-8365-9710

Funding

National Natural Science Foundation of China 82370579

6 · The paper itself

Abstract

While lifestyle interventions (LSI) are the cornerstone of metabolic dysfunction-associated steatotic liver disease (MASLD) management, the molecular mechanisms driving the histological and metabolic regression in LSI-responsive patients remain unclear. C57BL/6N mice were hydrodynamically injected with Slc25a4 and Sleeping Beauty transposon. Single-cell RNA sequencing (scRNA-seq) profiled the hepatic immune landscape. Metabolomics and co-culture assays analyzed intercellular crosstalk. Responsive MASLD patients had high SLC25A4 expression, correlating with exercise-induced hepatic steatosis improvement. Slc25a4 overexpression augmented exercise effects. scRNA-seq identified a distinct population of Clec4f

Indexed as

ExerciseMacrophageMASLDPANX1SLC25A4

Identifiers

PMID42881487

DOI10.1002/advs.78004

PMCPMC13672689

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.