ArticleBMC oral health2026
The impact of photobiomodulation therapy by diode lasers at wavelengths of 450 nm, 980 nm and their combinations on the proliferation and differentiation of periodontal ligament mesenchymal stem cells.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was conducted to investigate the effects of photobiomodulation utilizing a 450, 980 nm laser and a combination of these wavelengths on the growth and differentiation of periodontal ligament mesenchymal stem cells (PDLMSCs).
methodPDLMSCs were cultured and assessed in four groups. The first one received 450 nm, the second 980 nm. Each received 4 J/cm
resultIn the MTT experiment on days 2 and 4, the 980 nm group had the highest cell proliferation rate, but the mix group had a control group-like rate on day 4. RT-PCR showed that the 980 nm group differentiated highest, followed by the 450 nm group at a lower rate. In contrast, the mixed group showed results similar to or lower than the control except for OPN expression. 980 nm group had the most alizarin red mineralization. The mixed group had the most apoptosis.
conclusionIt was demonstrated that 450 nm and 980 nm laser photobiomodulation increased PDLMSC proliferation and osteogenic differentiation. Combining these wavelengths did not affect cell growth or differentiation.
Indexed as
Identifiers
42881462What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.