Evidence map›Paper›PMID 42881417›Full record

ArticleMolecular neurodegeneration2026

SALL1 as a marker for distinguishing microglia from blood-derived myeloid cells in stroke brain scRNA-seq data.

Chu-Yan Zhang, Yi-Ming Lu, Heng Zhang, Yi-Sheng Li, Luo-Yi-Fan He, Yi-Yao Gao, Mu-Zhou Xue, Zi-Yu Wang, Zi-Bo Tang, Li-Li Feng and 2 more

Abstract read
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In one paragraph

Article in Molecular neurodegeneration, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chu-Yan Zhang *Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Yi-Ming Lu *Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Heng Zhang *Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Yi-Sheng LiMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Luo-Yi-Fan HeMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Yi-Yao GaoMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Mu-Zhou XueMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Zi-Yu WangMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Zi-Bo TangMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Li-Li FengMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China. fenglilinjmu@njmu.edu.cn.
Jiali WangMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China. q1467517@163.com.ORCID 0000-0001-8801-6899
Yi-Xuan ZhangMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China. yxzhang@njmu.edu.cn.ORCID 0000-0001-9781-6281

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Distinguishing resident microglia from infiltrating myeloid cells in stroke scRNA-seq data remains challenging due to shared myeloid markers; SALL1 shows greater specificity for microglia compared with commonly used markers (e.g. TMEM119, CX3CR1, P2RY12), and combining SALL1 with these commonly used markers improves the ability to distinguish microglia from infiltrating myeloid populations in stroke‑associated scRNA‑seq datasets.

Indexed as

BrainMicrogliaMyeloid CellsStrokeTranscription FactorsAnimalsBiomarkersHumansBiomarkersTranscription FactorsMarker geneMicrogliaMyeloid cellsPBMCsSALL1ScRNA-seqStroke

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.