Evidence map›Paper›PMID 42881274›Full record

ArticleNature metabolism2026

IRF7 signalling in tanycytes controls brain-body-immune response across the ovarian cycle.

Sreekala Nampoothiri, Daniela Fernandois, Nathalie Journiac, Fabien Delahaye, Yvon Mbouamboua, Florent Sauve, Marie Couralet, Sarah Gallet, Naziha Mroueh, Maria Laura Serradas Aponte and 16 more

Abstract read
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In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Sreekala NampoothiriUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France. sreekala.nampoothiri@inserm.fr.ORCID http://orcid.org/0000-0001-9880-0636
Daniela Fernandois *Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-8282-0189
Nathalie Journiac *Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.
Fabien Delahaye *Univ. Lille, Inserm, CNRS, Institut Pasteur de Lille, CHU Lille, Laboratory of Metabolic functional (epi)genomics and their abnormalities in Type 2 diabetes and related disorders, UMR 1283/8199, EGID, Lille, France.
Yvon MbouambouaUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-7764-829X
Florent SauveUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-5070-8627
Marie CouraletUniversité Côte d'Azur, CNRS, Inserm, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.ORCID http://orcid.org/0000-0002-4581-8418
Sarah GalletUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-9285-4083
Naziha MrouehBiology of Inflammation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0009-0003-8316-9839
Maria Laura Serradas AponteInstitute for Neurovascular Cell Biology, Faculty of Medicine, University of Bonn, Bonn, Germany.
Nathalie JouyPlateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41, Inserm, Lille, France.
Rachel SpenleUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.
Ruth Schmidt-UllrichDepartment of Hypertension-Mediated End-Organ Damage, Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft, Berlin, Germany.ORCID http://orcid.org/0000-0002-2472-6530
Ines Martinez CorralUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0001-9194-2412
Virginie MattotUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-3996-7783
Carmen Ruiz de AlmodovarInstitute for Neurovascular Cell Biology, Faculty of Medicine, University of Bonn, Bonn, Germany.
Andreas SchlitzerBiology of Inflammation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-7662-3712
Philippe FroguelUniv. Lille, Inserm, CNRS, Institut Pasteur de Lille, CHU Lille, Laboratory of Metabolic functional (epi)genomics and their abnormalities in Type 2 diabetes and related disorders, UMR 1283/8199, EGID, Lille, France.ORCID http://orcid.org/0000-0003-2972-0784
Claude-Alain MaurageUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.
Pascal BarbryUniversité Côte d'Azur, CNRS, Inserm, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.ORCID http://orcid.org/0000-0001-9632-6483
Paolo GiacobiniUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France.ORCID http://orcid.org/0000-0002-3075-1441
Lennart T MarsUniv. Lille, Inserm, CHU Lille, Laboratory of Neuroinflammation & Multiple Sclerosis, Lille Neuroscience & Cognition, UMR-S1172, Lille, France.
Amelie BonnefondUniv. Lille, Inserm, CNRS, Institut Pasteur de Lille, CHU Lille, Laboratory of Metabolic functional (epi)genomics and their abnormalities in Type 2 diabetes and related disorders, UMR 1283/8199, EGID, Lille, France.ORCID http://orcid.org/0000-0001-9976-3005
Ruben NogueirasUniversidade de Santiago de Compostela-Instituto de Investigation Sanitaria, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0002-9976-9930
Markus SchwaningerInstitute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-4510-9718
Vincent PrevotUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, France. vincent.prevot@inserm.fr.ORCID http://orcid.org/0000-0001-7185-3615

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-10-EQPX-07-01Agence Nationale de la Recherche (French National Research Agency) ANR-10-INBS-009Agence Nationale de la Recherche (French National Research Agency) ANR-10-INBS-09-03Agence Nationale de la Recherche (French National Research Agency) ANR-19-P3IA-0002Agence Nationale de la Recherche (French National Research Agency) ANR-25-CE16-4744-01Agence Nationale de la Recherche (French National Research Agency) PPIA 4D-OMICS ANR-21-ESRE-0052EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 810331Novo Nordisk Foundation Center for Basic Metabolic Research (NovoNordisk Foundation Center for Basic Metabolic Research) NNF23SA0088590
6 · The paper itself

Abstract

Sex-specific differences in metabolic and immune function are shaped by endocrine-immune interactions, yet the complexity of this relationship remains poorly understood. Here, we identify an immune cell-like state of tanycytes, an ependymoglial cell type lining the third ventricle that mediates brain-body communication

Identifiers

PMID42881274

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