Evidence map›Paper›PMID 42881231›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Sex differences in circulating endocannabinoid concentrations during adolescence: Associations with pubertal development.

Julia M Evanski, Tristin Smith, Adriene M Beltz, Esmeralda Hidalgo-Lopez, Christel M Portengen, Andrew Schrepf, Steven E Harte, Chelsea M Kaplan

Abstract read
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In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia M EvanskiNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Tristin SmithDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Adriene M BeltzDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5754-8083
Esmeralda Hidalgo-LopezDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8521-8970
Christel M PortengenDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Andrew SchrepfDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Steven E Harte *Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Chelsea M Kaplan *Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA. chelsmar@med.umich.edu.ORCID http://orcid.org/0000-0001-9324-655X

Funding

Behavioral and neurobiological predictors of widespread pain in early adolescence and sex-specific trajectories of pain during pubertyR01NR020013 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Adriene M. Beltz, Chelsea Kaplan · 2022 to 2026
$2.3M
Effects of Cannabinoids on Endocannabinoid Regulation, Sensory Processing, and Pain Neurobiology in Knee OsteoarthritisF31DA066087 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julia Evanski · 2026 to 2026
$44k
U.S. Department of Health & Human Services | NIH | National Institute of Nursing Research (NINR) R01 NR020013U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) F31DA066087
6 · The paper itself

Abstract

Endocannabinoids contribute to sex-related processes, including puberty. In 1,159 adolescents, females showed significantly lower concentrations than males across five endocannabinoids (AEA, 2-AG, PEA, OEA, and 2-OG). Sex-by-puberty interactions were significant for AEA, PEA, and OEA. Exploratory analyses revealed sex-specific associations between endocannabinoids and self-reported pain, stress, internalizing, and attentional problems.

Identifiers

PMID42881231

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.