Evidence map›Paper›PMID 42881223›Full record

ArticleNature neuroscience2026

A half-center oscillator regulates sleep pressure.

Peter S Hasenhuetl, Raffaele Sarnataro, Eleftheria Vrontou, H Olof Rorsman, Clifford B Talbot, Ruth Brain, Gero Miesenböck

Abstract read
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In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peter S Hasenhuetl *Centre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3121-9502
Raffaele Sarnataro *Centre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-2977-542X
Eleftheria VrontouCentre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK.
H Olof RorsmanCentre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-8263-2460
Clifford B TalbotCentre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK.ORCID http://orcid.org/0009-0002-9820-3342
Ruth BrainCentre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK.
Gero MiesenböckCentre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK. gero.miesenboeck@cncb.ox.ac.uk.ORCID http://orcid.org/0000-0003-2940-3228

Funding

Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) J 4060EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)) 832467Wellcome Trust (Wellcome) 106988/Z/15/ZWellcome Trust (Wellcome) 215200/Z/19/Z
6 · The paper itself

Abstract

Changes in oscillatory neural dynamics reflect-but may not necessarily determine-transitions between sleep stages and variations in sleep pressure. Here we show that sleep-control neurons innervating the dorsal fan-shaped body of Drosophila (dFBNs) produce slow-wave activity (SWA) that is causally linked to sleep. The dFBN ensemble contains bistable cells whose membrane voltages oscillate between hyperpolarized DOWN and depolarized UP states. The oscillations rely on interhemispheric competition of two half-centers connected by inhibitory glutamatergic synapses. dFBN-restricted interference with glutamate release disrupts SWA and baseline as well as rebound sleep, whereas the optogenetic replay of SWA induces sleep. dFBNs generate SWA throughout the sleep-wake cycle (despite mutual antagonism with arousing dopaminergic neurons) and adjust its power to sleep need via sleep history-dependent increases in excitability and homeostatic synaptic depression. The oscillatory format permits a continuous encoding of sleep pressure but requires mechanisms that convert the amplitude-modulated signal into binary sleep-wake states.

Identifiers

PMID42881223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.