ReviewNPJ precision oncology2026
Spatiotemporal multi-omics reveals lineage, spatial and functional heterogeneity of tumor-associated macrophages and therapeutic vulnerabilities in the tumor microenvironment.
Review in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
Funding
Abstract
Tumor-associated macrophages (TAMs) are central orchestrators of immune evasion, therapeutic resistance, and clinical outcome across diverse solid tumors. However, the classical M1/M2 paradigm fails to capture the lineage diversity, spatial heterogeneity, and functional plasticity of TAMs within the tumor microenvironment. Unlike previous reviews that mainly summarize macrophage polarization or TAM subtype classification, this review focuses on how emerging single-cell and spatial multi-omics technologies redefine TAM ontogeny, phenotypic diversity, spatial organization, and therapeutic vulnerabilities. This review summarizes how fate-mapping, single-cell transcriptomics, and spatial multi-omics have contributed to the understanding of the dual origins of TAMs, including embryo-derived tissue-resident macrophages and monocyte-derived macrophages, and how these technologies further delineate transcriptionally and functionally distinct TAM subsets such as SPP1
Identifiers
42881205What OpenQuestion holds
Registered trials
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