Evidence map›Paper›PMID 42881202›Full record

Articlenpj aging2026

Polygenic scores for longevity in relation to brain MRI measures in a cohort of 70-year-olds.

Nazib M Seidu, Olof Lindberg, Silke Kern, Lina Rydén, Lars-Olof Wahlund, Margda Waern, Rosaleena Mohanty, Nira Cedres, Henrik Zetterberg, Kaj Blennow and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nazib M SeiduNeuropsychiatric Epidemiology (EPINEP), Centre for Ageing and Health (AgeCap), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. nazib.m.seidu@gu.se.ORCID https://orcid.org/0000-0002-8381-9657
Olof LindbergDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Silke KernDepartments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Lina RydénDepartments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-3817-2620
Lars-Olof WahlundDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Margda WaernDepartments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Rosaleena MohantyDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Nira CedresDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hanna Falk ErhagDepartments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Anna ZettergrenDepartments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Eric Westman *Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3115-2977
Henne Holstege *Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.
Ingmar Skoog *Departments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

Funding

AGECAP 2013-2300, 2013-2496, 2018-00471Alzheimerfonden AF-554461, AF-647651, AF-743701, AF-844671, AF-930868, AF-940139, AF-968441, AF-980935, AF-1012063, AF-1032314, AF-842471, AF-737641, AF-929959, AF-939825, AF-967495, AF-980387Olle Engkvists Foundation (Olle Engkvists Stiftelse) 186-0660, 224-0069Swedish Research Council for Health, Working Life and Welfare 2013-1202, 2016-07097, 2018-00471,The ALF-agreement ALFGBG-1006423, ALF-965812, ALF-716681, ALFGBG-71320,ALFGBG-1005471, ALFGBG-965923, ALFGBG-81392, ALF GBG-771071, FoUI-952838, FoUI-954893The Center for Innovative Medicine (CIMED) FoUI-954459, FoUI-975174The Swedish Brain Foundation FO2024-0097,FO2014-0207, FO2016-0214, FO2018-0214, FO2019-0163, FO2020-0235, FO2021-0213, FO2024-0341, FO2024-0341-HK-76, FO2022-0084, FO2024-0239The Swedish Parkinson's foundation (Parkinsonfonden) 1557/2024, 1521/23The Swedish Research Council 2012-5041, 2015-02830, 2013-8717, 2016-01590, 2017-00639, 2019-01096, 2019-02397, 2022-00882, 2022-01018, 2023-00356, 2019-02075, 2019-02075_15,2016-02282, 2021-01861
6 · The paper itself

Abstract

Population-based studies on the relation between polygenic longevity scores (PGLSs) and specific brain regions on magnetic resonance imaging (MRI) are few. We aimed to investigate this relationship in a population of 70-year-olds from Gothenburg, Sweden (N = 675). We constructed two PGLSs (one with and one without the APOE locus) using longevity GWAS summary statistics. MRI outcomes included total grey matter, white matter (WM), WM hyperintensities (WMHs), subcortical volumes, small vessel disease (SVD) score, cortical thicknesses, and fractional anisotropy (FA) fibre tracts. We adjusted for sex, age, principal components, and sex interactions, and corrected for multiple comparisons. We found no associations in the total sample. In males, both PGLSs were associated with smaller WMHs volume and lower SVD burden, and a thicker cortex of pars triangularis, pars opercularis, and insula. Our findings suggest a possible link between genetic propensity for longevity and lower cerebrovascular burden and certain cortical grey matter areas in males.

Identifiers

PMID42881202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.