Evidence map›Paper›PMID 42881193›Full record

ArticleNature communications2026

Klebsiella-dominant gut communities are associated with impeded oral rotavirus vaccine response in infants.

Cale O Seymour, Gertrude Ecklu-Mensah, Yesun Lee, Alexander R Nicols, Wesley A Cheng, Jaycee M Jumarang, Carolyn Jennifer Marentes Ruiz, Jocelyn Navarro, Rafaella Navarro, Yamile Rodriguez-Angeles and 7 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cale O Seymour *Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Gertrude Ecklu-Mensah *Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Yesun LeeDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Alexander R NicolsDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1813-3819
Wesley A ChengDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Jaycee M JumarangDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Carolyn Jennifer Marentes RuizDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Jocelyn NavarroDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Rafaella NavarroInstituto de Medicina Tropical Alexander von Humboldt and Laboratorios de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia, Lima, Peru.
Yamile Rodriguez-AngelesInstituto de Medicina Tropical Alexander von Humboldt and Laboratorios de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID http://orcid.org/0000-0001-5149-4950
David DurandInstituto de Medicina Tropical Alexander von Humboldt and Laboratorios de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID http://orcid.org/0000-0002-9296-2850
Sarah M AllardDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Zackary W TaylorDepartment of Pediatrics, Kaiser Permanente, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2864-3855
Ruth G De LeónDepartment of Sexual and Reproductive Health, Gorgas Memorial Institute for Health Studies, Panama City, Panama.
Theresa J OchoaInstituto de Medicina Tropical Alexander von Humboldt and Laboratorios de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia, Lima, Peru.
Jack A GilbertDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7920-7001
Pia S PannarajDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA. ppannaraj@ucsd.edu.ORCID http://orcid.org/0000-0002-5208-0933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rotavirus gastroenteritis is the leading cause of infant diarrheal death worldwide. Oral rotavirus vaccine (RVV) prevents illness and death, but efficacy differs between high- and low-income countries and the etiologies are unclear. Here, we describe the relationship between colonization of the infant gut by commensal bacteria, inflammation, and vaccine response across a cohort of infants from Panama, Peru, and the U.S. Vaccine immunogenicity was related to community composition in the first month of life and inverse to increased relative abundance of Klebsiella. Clustering communities into gut types revealed that microbiome configurations with elevated Klebsiella or Escherichia in the first month of life were negatively associated with both seroconversion and rotavirus shedding after vaccination, suggesting potential inhibition of vaccine function or host response. Infants without RVV strain shedding displayed elevated fecal calprotectin in the first month. These results implicate microbiome-augmented infant gut inflammation as a potential impediment to RVV response.

Indexed as

Gastrointestinal MicrobiomeKlebsiellaRotavirus InfectionsRotavirus VaccinesAdministration, OralFecesFemaleGastroenteritisHumansImmunogenicity, VaccineInfantLeukocyte L1 Antigen ComplexMalePeruRotavirusVirus SheddingLeukocyte L1 Antigen ComplexRotavirus Vaccines

Identifiers

PMID42881193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.