Evidence map›Paper›PMID 42881166›Full record

ArticleNature communications2026

Ablation of CDK6 and STAT5B rewires T cell developmental dynamics and prevents ALK

Jonatan Kendler, Maximilian Sexl, Alessia Schirripa, Elisabeth Gamper, Hager El Kersh, Barbara Maurer, Reinhard Grausenburger, Klavdija Krause, Dua Shahid, Alexander Pichler and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jonatan KendlerDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0002-2470-4868
Maximilian SexlDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Alessia SchirripaDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0001-5446-9136
Elisabeth GamperDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0009-0007-8439-4148
Hager El KershDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0009-0006-5312-6039
Barbara MaurerDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Reinhard GrausenburgerDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Klavdija KrauseDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0002-8383-1330
Dua ShahidDepartment of Internal Medicine I (Oncology, Hematology, Clinical Immunology, and Rheumatology), Saarland University Medical School, Homburg, Germany.ORCID http://orcid.org/0009-0001-6028-4696
Alexander PichlerDepartment of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Giorgia DamonteDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0009-0000-5739-3966
Tania BrandstoetterDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0003-4037-5352
Michaela Prchal-MurphyDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Stefania MassariDepartment of Biological Sciences and Pathobiology, Unit of Pathology, University of Veterinary Medicine, Vienna, Austria.
Sabine LaggerDepartment of Biological Sciences and Pathobiology, Unit of Pathology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0002-3032-9910
Lukas KennerDepartment of Biological Sciences and Pathobiology, Unit of Pathology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0003-2184-1338
Richard MorigglDepartment of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Salzburg, Austria.ORCID http://orcid.org/0000-0003-0918-9463
Philipp B StaberDepartment of Internal Medicine I (Oncology, Hematology, Clinical Immunology, and Rheumatology), Saarland University Medical School, Homburg, Germany.
Veronika SexlDepartment of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Sebastian Kollmann *Department of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Karoline Kollmann *Department of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria. Karoline.Kollmann@vetmeduni.ac.at.ORCID http://orcid.org/0000-0002-7937-4245
Thorsten Klampfl *Department of Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria. Thorsten.Klampfl@vetmeduni.ac.at.ORCID http://orcid.org/0000-0002-6666-9773

Funding

Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) P 34269Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) SFB F6101Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) SFB F6107
6 · The paper itself

Abstract

CDK6 and STAT5B are well-established oncogenic drivers, but their interplay during transformation remains poorly understood. Here, we demonstrate that simultaneous genetic deletion of Cdk6 and Stat5b in an NPM-ALK

Indexed as

Anaplastic Lymphoma KinaseCyclin-Dependent Kinase 6Lymphoma, Large-Cell, AnaplasticSTAT5 Transcription FactorT-LymphocytesAnimalsApoptosisCell DifferentiationFemaleGene Expression Regulation, NeoplasticHumansMiceMice, KnockoutMice, TransgenicProtein-Tyrosine KinasesThymocytesAlk protein, mouseAnaplastic Lymphoma KinaseCdk6 protein, mouseCyclin-Dependent Kinase 6p80(NPM-ALK) proteinProtein-Tyrosine KinasesSTAT5B protein, humanStat5b protein, mouseSTAT5 Transcription Factor

Identifiers

PMID42881166

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.