Evidence map›Paper›PMID 42881160›Full record

Trial reportNature communications2026

Effect of dietary chickpea structures on the small intestine metabolome and microbiome: a randomised crossover trial.

Nadia Fernandes, Mingzhu Cai, Frederick J Warren, Anthony Duncan, Hannah Harris, Jose Ivan Serrano Contreras, Katarzyna Sidorczuk, Andres Bernal, Andres Castillo, Katerina Petropoulou and 8 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nadia Fernandes *Section for Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. nadia.fernandes@kennedy.ox.ac.uk.ORCID http://orcid.org/0000-0003-4595-9939
Mingzhu Cai *Section for Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. m.cai18@imperial.ac.uk.ORCID http://orcid.org/0000-0002-1474-0224
Frederick J Warren *Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0002-2512-4670
Anthony DuncanQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0002-3849-9527
Hannah HarrisQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Jose Ivan Serrano ContrerasSection for Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-8669-7571
Katarzyna SidorczukQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0001-6576-9054
Andres BernalAustralian National Phenome Centre and Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA, Australia.ORCID http://orcid.org/0000-0003-1668-7225
Andres CastilloAustralian National Phenome Centre and Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA, Australia.
Katerina PetropoulouSection for Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-4680-9246
Dominic BluntDepartment of Imaging, Charing Cross Hospital, Imperial NHS Trust, London, UK.
Natalia Perez-MoralQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0002-4544-9165
Isabel Garcia-PerezSection for Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-8398-0603
Cathrina EdwardsQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0003-4952-0229
Falk HildebrandQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Elaine HolmesSection for Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-0556-8389
Julien WistAustralian National Phenome Centre and Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA, Australia.ORCID http://orcid.org/0000-0002-3416-2572
Gary FrostSection for Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. g.frost@imperial.ac.uk.ORCID http://orcid.org/0000-0003-0529-6325

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X018857/1
6 · The paper itself

Abstract

The human gastrointestinal tract (GIT) is central to human physiology, yet our understanding of the metabolite, microbial, and hormonal spatiotemporal dynamics in humans is limited. How these environments respond to complex food structures and homeostatic mechanisms they generate is unknown in humans. In this randomised study, ten participants consumed chickpea-based meals with intact versus broken cellular structures, with sampling of oral, gastric, duodenal and ileal fluids. The primary outcome was the postprandial enteroendocrine hormone responses (GIP, GLP-1 and PYY); secondary outcomes were GIT metabolite profiles (

Indexed as

CicerDietGastrointestinal MicrobiomeIntestine, SmallMetabolomeAdultCross-Over StudiesFemaleGastric Inhibitory PolypeptideGlucagon-Like Peptide 1HumansIleumPeptide YYPostprandial PeriodYoung AdultGastric Inhibitory PolypeptideGlucagon-Like Peptide 1Peptide YY

Identifiers

PMID42881160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.