ArticleNature communications2026
LENG8 granule regulates alternative polyadenylation in mammals.
Zhicheng Wu, Chen Du, Yinming Li, Xueying Huang, Youwan Qin, Ai Zhong, Ming Rao, Fengming Liu, Hongwen Zhu, Yu Zhou and 1 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 · Who and what moneyAuthors and funding
11 authors.
Zhicheng Wu *Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Yinming Li *College of Life Sciences, TaiKang Center for Life and Medical Sciences, RNA Institute, Wuhan University, Wuhan, China.
Xueying HuangClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Youwan QinClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Ai ZhongCenter for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Ming RaoCenter for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Fengming LiuNational Center for Protein Science Shanghai, Shanghai, China.
Peng DaiClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China. daipeng@tongji.edu.cn.ORCID http://orcid.org/0009-0001-0915-3033 Funding
National Natural Science Foundation of China (National Science Foundation of China) 32171287National Natural Science Foundation of China (National Science Foundation of China) 324B2009National Natural Science Foundation of China (National Science Foundation of China) 32525018National Natural Science Foundation of China (National Science Foundation of China) 82341023National Natural Science Foundation of China (National Science Foundation of China) 82401650Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 228001437
6 · The paper itselfAbstract
Membraneless organelles (MLOs) participate in multiple cellular processes and layers of gene regulation. Alternative polyadenylation (APA) represents a pervasive gene regulatory mechanism that generates distinct 3' untranslated regions (UTRs) in transcripts. However, whether specific MLOs exist in mammals to regulate APA remains largely unknown. Here, we unveil a nuclear body, termed the LENG8 granule (G granule), that functions as an active hub for APA regulation. LENG8 deletion induces extensive 3'UTR lengthening in both cultured cells and male germ cells. Mechanistically, phase separation-driven LENG8 granule formation facilitates LENG8-CPSF4 interaction and promotes the subsequent assembly of the cleavage and polyadenylation (CPA) complex, thereby favoring proximal poly(A) site usage in target transcripts. We further elucidate that YTHDC1-m
Indexed as
Cytoplasmic GranulesPolyadenylation3' Untranslated RegionsAnimalsCleavage And Polyadenylation Specificity FactorHumansMaleMicePhase SeparationRNA-Binding ProteinsRNA, Messenger3' Untranslated RegionsCleavage And Polyadenylation Specificity FactorRNA-Binding ProteinsRNA, Messenger
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