Evidence map›Paper›PMID 42881149›Full record

ArticleNature communications2026

Epithelial-mesenchymal Wnt crosstalk directs planar cell polarity in the developing cochlea.

Ippei Kishimoto, Abel P David, Kevin P Rose, Balasubramanian Narasimhan, Bradley Efron, Sara E Billings, Erin L Su, Wuxing Dong, Taha A Jan, Ronna Hertzano and 1 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ippei KishimotoDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1442-7470
Abel P DavidDepartment of Otolaryngology-Head & Neck Surgery, Northwestern Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1687-8240
Kevin P RoseSection on Omics and Translational Science of Hearing, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Balasubramanian NarasimhanDepartment of Statistics, Stanford University, Stanford, CA, USA.
Bradley EfronDepartment of Statistics, Stanford University, Stanford, CA, USA.
Sara E BillingsDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5512-8675
Erin L SuDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Wuxing DongDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Taha A JanDepartment of Otolaryngology - Head and Neck Surgery, Epithelial Biology Center, Vanderbilt Center for Stem Cell Biology, Center for Computational Systems Biology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-8971-7769
Ronna HertzanoSection on Omics and Translational Science of Hearing, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Alan G ChengDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA. aglcheng@stanford.edu.ORCID http://orcid.org/0000-0002-4702-8401

Funding

Mouse vestibular regeneration and functionR01DC016919 · NIDCD · STANFORD UNIVERSITY · PI Alan Gi-Lun Cheng · 2019 to 2026
$4.9M
Molecular basis of mammalian cochlear regenerationR01DC021110 · NIDCD · STANFORD UNIVERSITY · PI Alan Gi-Lun Cheng · 2023 to 2026
$2.6M
U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC016919U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC021110
6 · The paper itself

Abstract

Cochlear hair cells are precisely oriented by planar cell polarity. Wnt proteins direct planar cell polarity in vertebrates, but their roles in regulating cochlear planar cell polarity remain unclear. Here, we inhibit Wnt secretion by ablating epithelial Wntless and find shortened cochlea, mild hair cell misorientation and mislocalization of core planar cell polarity proteins, Fzd6 and Dvl2. Computational analysis predicts that epithelial Wnts (Wnt5a, Wnt7a, Wnt7b) and Wnt5a from surrounding periotic mesenchyme act on developing hair cells. Deletion of epithelial Wnt5a, Wnt7a, and Wnt7b additively shortens the cochlea without causing hair cell misorientation or Fzd6/Dvl2 mislocalization. Moreover, deletion of epithelial or both epithelial and mesenchymal Wnt5a fails to cause polarity defects. However, ablating both epithelial and mesenchymal Wntless severely shortens the cochlea and causes hair cell misorientation and mislocalized core planar cell polarity proteins. Thus, Wnts serve as global instructive cues directing cochlear outgrowth and hair cell polarization, with remarkable redundancy of distinct Wnts across epithelial and mesenchymal compartments to ensure a fail-safe developmental program.

Indexed as

Cell PolarityCochleaMesodermWnt ProteinsAnimalsDishevelled ProteinsEpithelial CellsFrizzled ReceptorsHair Cells, AuditoryMiceWnt-5a ProteinWnt Signaling PathwayDishevelled ProteinsDvl2 protein, mouseFrizzled ReceptorsFzd6 protein, mouseWnt-5a ProteinWnt5a protein, mouseWnt7a protein, mouseWnt Proteins

Identifiers

PMID42881149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.