ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026
[Clinical characteristics and risk factors of patients with rheumatoid arthritis complicated with urinary tract infection].
Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo explore the clinical characteristics of urinary tract infection (UTI) in patients with rheumatoid arthritis (RA), to evaluate the effects of different treatment regimens on the risk of UTI, and to identify independent risk factors for UTI complicated with RA.
methodsA retrospective cohort study was conducted. RA patients hospitalized in the Department of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College from September 2020 to September 2023 were enrolled. General clinical data, laboratory indicators and medication information of the patients were collected. Patients were divided into two groups according to the presence or absence of UTI for comparative analysis. Patients were grouped based on different treatment regimens received, and the proportions of UTI occurrence were compared among each group. The results of urine culture and drug susceptibility test in the RA patients with UTI were analyzed. Univariate and multivariate Logistic regression analyses were further performed to screen relevant factors for UTI in the RA patients, and the diagnostic value of combined indicators was assessed using receiver operating characteristic (ROC) curve.
resultsA total of 196 RA patients were included, among whom 99 cases were complicated with UTI and 97 cases without UTI. Compared with the non-UTI group, the UTI group had higher proportions of female patients, patients aged ≥65 years, patients with RA disease duration ≥10 years, patients hospitalized for infection within the past two years, and patients with comorbidities (diabetes mellitus, hypertension, etc.). Peripheral blood leukocyte count, percentage of neutrophils, serum procalcitonin, erythrocyte sedimentation rate (ESR) and C-reactive protein level were elevated (
conclusionClinical infection surveillance should be strengthened in RA patients. GCs should be rationally used on the premise of effective RA disease control, and bDMARDs/tsDMARDs therapy should be initiated timely according to disease status to reduce GCs exposure and minimize the risk of UTI. Meanwhile, antimicrobial agents should be selected in a standardized manner based on urine culture and drug susceptibility test results.
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