Evidence map›Paper›PMID 42880909›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026

[Selenium-containing polyurethane-modified titanium modulates osteogenic differentiation of mesenchymal stem cells and M2 polarization of macrophages].

Mo Zhai, Xiaoqiang Bai, Yang Fu, Huaping Xu, Yongsheng Zhou, Longwei Lv

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Mo ZhaiInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
Xiaoqiang BaiDepartment of Prosthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Beijing Key Laboratory for Intelligent Biomanufacturing and Regeneration of Craniofacial Tissues & NHC Key Laboratory of Digital Stomatology, Beijing 100081, China.
Yang FuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Beijing Key Laboratory for Intelligent Biomanufacturing and Regeneration of Craniofacial Tissues & NHC Key Laboratory of Digital Stomatology, Beijing 100081, China.
Huaping XuDepartment of Chemistry, Tsinghua University, Beijing 100084, China.
Yongsheng ZhouInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
Longwei LvDepartment of Prosthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Beijing Key Laboratory for Intelligent Biomanufacturing and Regeneration of Craniofacial Tissues & NHC Key Laboratory of Digital Stomatology, Beijing 100081, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo address the issue of implant failure in clinical titanium implants due to inflammation, disease microenvironments, poor osseointegration through surface modification, and to explore the regulatory effects of selenium-containing biomaterial-modified titanium on the osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMMSCs) and the M2 polarization of RAW 264.7 cells.

methodsSelenium-containing polyurethane (SePU) was synthesized, and titanium sheets were modified by immersion in SePU solutions at concentrations of 1, 3, and 5 g/L. Pure titanium sheets served as the control group. rBMMSCs and RAW 264.7 cells were then cultured on the modified titanium surfaces. The surface contact angles of the SePU-modified titanium sheets were characterized. After 2 days of culture, the effect of SePU-modified titanium on the viability of rBMMSCs and RAW 264.7 cells was observed using live/dead cell staining. The osteogenic differentiation of rBMMSCs was evaluated using alkaline phosphatase (ALP) staining and quantification, alizarin red S (ARS) staining and quantification, as well as the expression levels of osteogenic-related genes. The polarization state of RAW 264.7 cells was assessed by analyzing the expression levels of macrophage polarization-related genes.

resultsSePU-modified titanium sheets were successfully prepared and their surface contact angles increased with the immersion concentration. Following 2 days of culture, the majority of rBMMSCs and RAW 264.7 cells on both the pure titanium and SePU-modified titanium surfaces were viable, with only a negligible presence of dead cells. Notably, compared with the pure titanium group, the SePU-modified titanium groups exhibited more profound ALP and ARS staining, coupled with a statistically significant increase in the expression levels of osteogenic-related genes (

conclusionSePU-modified titanium not only exhibits increased surface contact angles but also has no significant effect on cell viability. It effectively promotes the osteogenic differentiation of rBMMSCs and the M2 polarization of RAW 264.7 cells, indicating its potential for enhancing bone regeneration and modulating immune responses in biomedical applications.

Indexed as

Cell DifferentiationMacrophagesMesenchymal Stem CellsOsteogenesisPolyurethanesSeleniumTitaniumAnimalsCells, CulturedMiceRatsRats, Sprague-DawleyRAW 264.7 CellsPolyurethanesSeleniumTitaniumbiocompatibleCoated materialsMacrophage activationMesenchymal stem cellsOsteogenesisSelenium-containing polyurethaneTitanium

Identifiers

PMID42880909
PMCPMC13672239

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.