Evidence map›Paper›PMID 42880908›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026

[Impact of icariin on the differentiation towards dentinogenesis and angiogenesis, and inflammatory regulation of stem cells from human exfoliated deciduous teeth].

Yu Jin, Liying Dong, Xiaojing Yuan, Rui Song, Zuoying Yuan, Yuming Zhao

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu JinDepartment of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Liying DongDepartment of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Xiaojing YuanDepartment of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Rui SongDepartment of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Zuoying YuanDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing 100871, China.
Yuming ZhaoDepartment of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the effects of icariin (ICA) on the proliferation and migration of stem cells from human exfoliated deciduous teeth (SHED), as well as its impact on dentinogenic and angiogenic differentiation

methods(1) SHED cells were cultured

results(1) In the 1, 10 μmol/L ICA intervention group, the proliferation ability of SHED cells was significantly enhanced; in the 0.1 μmol/L ICA intervention group, there was no significant change in the proliferation ability of SHED cells, and in the 20, 50 μmol/L ICA intervention group, the proliferation ability of SHED cells was significantly reduced. (2) In the 0.1, 1, 10 μmol/L ICA intervention group, the cell wound healing speed was faster. (3) In the 0.1, 1, 10 μmol/L ICA intervention group, the gene expression levels of

conclusionSuitable concentrations of ICA can promote the proliferation, migration and odontoblast-like differentiation of SHED cells, enhance their angiogenic ability, and have a certain anti-inflammatory effect.

Indexed as

AngiogenesisCell DifferentiationFlavonoidsNeovascularization, PhysiologicStem CellsTooth, DeciduousCell MovementCell ProliferationCells, CulturedDentin SialophosphoproteinExtracellular Matrix ProteinsHumansInterleukin-8PhosphoproteinsSialoglycoproteinsVascular Endothelial Growth Factor ADentin SialophosphoproteinDMP1 protein, humanExtracellular Matrix ProteinsFlavonoidsicariinInterleukin-8PhosphoproteinsSialoglycoproteinsVascular Endothelial Growth Factor AIcariinPulpitisStem cells from human exfoliated deciduous teeth

Identifiers

PMID42880908
PMCPMC13672245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.