Evidence map›Paper›PMID 42880820›Full record

ArticleJournal for immunotherapy of cancer2026

Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels.

Jingyuan Wang, Joanne Xiu, Alex P Farrell, Francesca Battaglin, Hiroyuki Arai, Yan Yang, Shivani Soni, Wu Zhang, Joshua Millstein, Anthony F Shields and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jingyuan WangDepartment of Medical Oncology, Cancer Center, Zhongshan Hospital Fudan University, Shanghai, China.
Joanne XiuCaris Life Sciences, Phoenix, Arizona, USA.
Alex P FarrellCaris Life Sciences, Phoenix, Arizona, USA.
Francesca BattaglinDivision of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID http://orcid.org/0000-0002-9869-0163
Hiroyuki AraiDivision of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID http://orcid.org/0000-0002-1886-7070
Yan YangDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Shivani SoniDivision of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Wu ZhangDivision of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Joshua MillsteinDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Anthony F ShieldsDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
Axel GrotheyGastrointestinal Cancer Research, West Cancer Center and Research Institute, Germantown, Tennessee, USA.
Benjamin A WeinbergRuesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.
John MarshallRuesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.
Emil LouDivision of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0002-1607-1386
Moh'd KhushmanDepartments of Medical Oncology, Washington University in St. Louis/Siteman Cancer Center, St. Louis, Missouri, USA.ORCID http://orcid.org/0000-0002-3095-5073
Davendra P S SohalUniversity of Cincinnati, Cincinnati, Ohio, USA.
Michael J HallDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Tianshu LiuDepartment of Medical Oncology, Cancer Center, Zhongshan Hospital Fudan University, Shanghai, China.
Matthew James OberleyCaris Life Sciences, Phoenix, Arizona, USA.
David SpetzlerCaris Life Sciences, Phoenix, Arizona, USA.
Heinz-Josef LenzDivision of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA lenz@med.usc.edu.ORCID http://orcid.org/0000-0003-2178-9568

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gastrointestinal CancerImmune Checkpoint InhibitorMicrosatelliteMismatch repair - MMR

Identifiers

PMID42880820

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.