Evidence map›Paper›PMID 42880793›Full record

ArticleBMJ open2026

A randomised, placebo-controlled study to assess whether antibiotic-mediated disruption of the gut microbiota impairs BCG-induced specific and non-specific immunity in young, healthy adults: protocol for the Antibiotics and Vaccine Immune Responses Study (AVIRS).

Natalie E Stevens, Rochelle Botten, James B Geake, Georgina L Eden, Wing Ki Lo, Joseph Inauen, Jelena Solujic, Alice Sawka, Lisa N Yelland, Elisabeth Wr Reid and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Natalie E StevensSystems Immunology Laboratory, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-7637-8013
Rochelle BottenClinical Trials Platform, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
James B GeakeDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0003-3864-8518
Georgina L EdenSystems Immunology Laboratory, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Wing Ki LoSystems Immunology Laboratory, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID http://orcid.org/0009-0002-0894-640X
Joseph InauenDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Jelena SolujicDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Alice SawkaDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Lisa N YellandSAHMRI Women and Kids, South Australian Health and Medical Research Institute, North Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0003-3803-8728
Elisabeth Wr ReidSystems Immunology Laboratory, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Michelle ShawClinical Trials Platform, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Xiaodan ZhuDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Tsz Kin TamDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0009-0009-5426-0178
Hyejin JeonDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Nelly AmenyogbeDepartment of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
Miriam A LynnSystems Immunology Laboratory, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0003-4300-1380
Feargal J RyanSystems Immunology Laboratory, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-1565-4598
Carl G FengImmunology and Host Defence Group, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4301-4640
Warwick J BrittonCentre for Infection and Immunity, Centenary Institute, Newtown, New South Wales, Australia.
Tobias R KollmannDepartment of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
Simone E BarryDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-6030-321X
David J LynnSystems Immunology Laboratory, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia david.lynn@sahmri.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AntibioticsGastrointestinal MicrobiomeIMMUNOLOGYRandomized Controlled TrialVaccination

Identifiers

PMID42880793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.