Evidence map›Paper›PMID 42880289›Full record

ArticleNeuron2026

Parvalbumin cell state dynamics regulate gamma oscillations and are disrupted in Alzheimer's disease.

Keran Ma, Kyerl Park, Patrick S Honma, Yutong Zhang, Erica Brady, Yuechen Qiu, Ximena Opitz-Araya, Jonathan T Ting, Boaz P Levi, Katerina Akassoglou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Keran MaGladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address: keran.ma@uth.tmc.edu.
Kyerl ParkGladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Patrick S HonmaGladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Yutong ZhangGladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
Erica BradyGladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Yuechen QiuGladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
Ximena Opitz-ArayaAllen Institute for Brain Science, Seattle, WA 98109, USA.
Jonathan T TingAllen Institute for Brain Science, Seattle, WA 98109, USA.
Boaz P LeviAllen Institute for Brain Science, Seattle, WA 98109, USA.
Katerina AkassoglouGladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA.
Jorge J PalopGladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: jorge.palop@gladstone.ucsf.edu.

Funding

Project 4: Cross-species Dissection of Cellular Response to APOE Genotype and AD Pathology Using Single-cell Multi-omicsP01AG073082 · NIA · J. DAVID GLADSTONE INSTITUTES · PI PALOP, JORGE J · 2021 to 2025
$23.4M
Neurovascular Interactions: Mechanisms, imaging, therapeutic potentialR35NS097976 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI AKASSOGLOU, KATERINA · 2016 to 2023
$11.1M
Multidimensional mapping of vulnerable cell types in humanized Alzheimer's disease mouse modelsR01AG082147 · NIA · STANFORD UNIVERSITY · PI Inma Cobos, Jorge J Palop · 2023 to 2026
$9.3M
Fibrinogen and vascular cognitive impairment: mechanisms, imaging, therapeuticsRF1AG064926 · NIA · J. DAVID GLADSTONE INSTITUTES · PI AKASSOGLOU, KATERINA, ELLISMAN, MARK H · 2019 to 2019
$4.5M
Cell type selective viral tools to interrogate and correct non-human primate and human brain circuitryUG3MH120095 · NIMH · ALLEN INSTITUTE · PI KALUME, FRANCK K, LEIN, ED · 2020 to 2022
$3.8M
Deciphering molecular pathways of inhibitory interneuron dysfunction in Alzheimer's diseaseR01AG062629 · NIA · J. DAVID GLADSTONE INSTITUTES · PI PALOP, JORGE J · 2019 to 2023
$3.6M
Cell type selective viral tools to interrogate and correct non-human primate and human brain circuitryUH3MH120095 · NIMH · ALLEN INSTITUTE · PI KALUME, FRANCK K, LEIN, ED · 2024 to 2025
$1.7M
Harnessing novel machine learning approaches for behavioral segmentation and brain signal integration in humanized models of Alzheimer's diseaseR01AG092683 · NIA · J. DAVID GLADSTONE INSTITUTES · PI Jorge J Palop · 2025 to 2026
$1.6M
Enhancer-AAVs to monitor and restore cell-type selective inhibitory deficits and circuit dysfunction in humanized Alzheimer's disease modelsR61AG094667 · NIA · J. DAVID GLADSTONE INSTITUTES · PI PALOP, JORGE J · 2025 to 2025
$1.5M
Neurovascular Interactions: Mechanisms, Imaging, TherapeuticsR35NS143067 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI AKASSOGLOU, KATERINA · 2025 to 2025
$1.4M
Functional Alterations of Parvalbumin Interneurons Contributing to Abnormal Network Activity in Alzheimer's Disease Mouse ModelsR00AG062776 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MA, KERAN · 2023 to 2025
$742k
Functional Alterations of Parvalbumin Interneurons Contributing to Abnormal Network Activity in Alzheimer's Disease Mouse ModelsK99AG062776 · NIA · J. DAVID GLADSTONE INSTITUTES · PI MA, KERAN · 2019 to 2021
$393k
NIA NIH HHS K99 AG062776NIA NIH HHS P01 AG073082NIA NIH HHS R00 AG062776NIA NIH HHS R01 AG062629NIA NIH HHS R01 AG082147NIA NIH HHS R01 AG092683NIA NIH HHS R61 AG094667NIA NIH HHS RF1 AG064926NIMH NIH HHS UG3 MH120095NIMH NIH HHS UH3 MH120095NINDS NIH HHS R35 NS097976NINDS NIH HHS R35 NS143067
6 · The paper itself

Abstract

Gamma oscillations are fundamental for cognitive processing, but the cellular and circuit dynamics that generate them remain poorly defined. Establishing a method for simultaneous calcium imaging and electrocorticography recordings in awake mice, we found that spontaneous gamma oscillations are accompanied by dynamic transitions between parvalbumin (PV) interneuron states. Rather than acting as a uniformly synchronized population, PV interneurons showed sequential recruitment, transient inactivation, and frequent transitions between activity states, indicating the formation of dynamic functional networks. In J20 Alzheimer's disease mice, these state transitions became dysregulated, leading to abnormal PV recruitment, impaired coupling between PV activity and gamma oscillations, and network hyperexcitability. Increasing interneuron excitability through expression of the voltage-gated sodium channel Nav1.1 restored PV cell dynamics, gamma oscillations, and network stability. These findings reveal dynamic PV cell states as an organizing feature of gamma oscillations and identify their disruption as a circuit mechanism of network dysfunction in Alzheimer's disease.

Indexed as

AlzheimerAPPcalcium imagingECoGepilepticGABAergicgamma oscillationshyperactivityNav1.1PV interneurons

Identifiers

PMID42880289
PMCPMC13673016

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.