Evidence map›Paper›PMID 42879678›Full record

ArticleAnnals of medicine2026

Metagenomic insights into the pulmonary microbiome of drug-sensitive and multidrug-resistant tuberculosis patients.

Zhi-Ruo Lin, Ji-Chan Shi, Chao-Chao Qiu, Zheng-Xing Wu, Xiao-Qing Lin, Gui-Qing He, Sai-Duo Liu, Qing-Wei Du, Hui-Bin Lin, Lian-Peng Wu and 2 more

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Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Zhi-Ruo LinInfectious Diseases Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.
Ji-Chan ShiInfectious Diseases Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.
Chao-Chao QiuInfectious Diseases Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.
Zheng-Xing WuInfectious Diseases Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.
Xiao-Qing LinInfectious Diseases Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.
Gui-Qing HeInfectious Diseases Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.
Sai-Duo LiuInfectious Diseases Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.
Qing-Wei DuInfectious Diseases Department, Shanghai First Hospital, Affiliated to Shanghai, Jiao Tong University School of Medicine, Shanghai, China.
Hui-Bin LinInfectious Diseases Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.
Lian-Peng WuMedical Laboratory Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.
Feng SunInfectious Diseases Department, Huashan Hospital Affiliated to Fudan University, National Center for Infectious Diseases Medicine, Shanghai, China.
Xian-Gao JiangInfectious Diseases Department, Wenzhou Central Hospital, Wenzhou Medical University Affiliated Wenzhou Central Hospital, Wenzhou Sixth People's Hospital, Wenzhou City, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile the pulmonary microbiota may influence TB pathogenesis, direct comparisons between drug-sensitive (DS-TB) and multidrug-resistant (MDR-TB) patients remain scarce. This study explored microbiome differences between these groups.

methodsBronchoalveolar lavage fluid (BALF) from 30 prospective patients (11 DS-TB, 19 MDR-TB) was analysed

resultsPatients with MDR-TB showed lower α-diversity and distinct β-diversity compared with patients with DS-TB. Streptococcus and Prevotella were relatively enriched in DS-TB, whereas Staphylococcus, Cutibacterium, and Mycobacterium were more abundant in MDR-TB. DS-TB showed enrichment of 45 carbohydrate-active enzyme families and core metabolic annotations, whereas MDR-TB showed enrichment of infection- and immunity-related functional annotations and a less connected taxonomic network. An exploratory random forest analysis identified six candidate genera and yielded an internally cross-validated AUC of 0.957.

conclusionsMDR-TB was associated with lower pulmonary microbial diversity, altered community composition, and shifts in predicted microbial functions. These findings characterise lower-airway microbiome differences between DS-TB and MDR-TB and provide a basis for further validation.

Indexed as

LungMicrobiotaTuberculosis, Multidrug-ResistantAdultAntitubercular AgentsBronchoalveolar Lavage FluidFemaleHumansMaleMetagenomicsMiddle AgedProspective StudiesAntitubercular Agentsbronchoalveolar lavage fluidmetagenomicsmicrobiotaTuberculosis, multidrug-resistant

Identifiers

PMID42879678
PMCPMC13674659

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