ArticleProceedings of the National Academy of Sciences of the United States of America2026
Global proteolysis during starvation governs proteome remodeling and a survival-regrowth trade-off in bacteria.
Gabriel Manzanarez, Rohan Balakrishnan, Harish Kannan, Miriam Abele, Hiroyuki Okano, Fukang She, Zhongge Zhang, Chenhao Wu, Lance Freiman, Christina Ludwig and 2 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Gabriel Manzanarez *Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093.
Rohan Balakrishnan *Department of Physics, University of California at San Diego, La Jolla, CA 92093.
Harish Kannan *Department of Mathematics, University of California at San Diego, La Jolla, CA 92093.ORCID 0009-0001-3908-0584 Miriam AbeleBavarian Center for Biomolecular Mass Spectrometry, School of Life Sciences, Technical University of Munich, Freising, Germany.
Hiroyuki OkanoDepartment of Physics, University of California at San Diego, La Jolla, CA 92093.
Fukang SheDepartment of Physics, University of California at San Diego, La Jolla, CA 92093.
Zhongge ZhangDivision of Biological Sciences, University of California at San Diego, La Jolla, CA 92093.
Chenhao WuDepartment of Physics, University of California at San Diego, La Jolla, CA 92093.
Lance FreimanDivision of Biological Sciences, University of California at San Diego, La Jolla, CA 92093.
Christina LudwigBavarian Center for Biomolecular Mass Spectrometry, School of Life Sciences, Technical University of Munich, Freising, Germany.ORCID 0000-0002-6131-7322 Terence HwaDivision of Biological Sciences, University of California at San Diego, La Jolla, CA 92093.ORCID 0000-0003-1837-6842 Funding
Quantitative Systemic Studies of Bacterial PhysiologyR35GM152133 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TERENCE HWA · 2024 to 2026
$1.8MBayerisch-Kalifornischen Hochschulzentrum (BaCaTeC) 2023-1DOW | National Defense Science and Engineering Graduate (NDSEG) graduate fellowshipEuropean Proteomics Infrastructure Consortium providing access (EPIC-XS) 823839German Research Foundation INST 95/1435-1 FUGGHHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM152133National Science Foundation (NSF) 2545232Simons Foundation (SF) 542387
6 · The paper itselfAbstract
Starving bacteria must synthesize stress proteins to survive, but how protein synthesis persists in the absence of nutrient influx is unclear. We show that in
Indexed as
Escherichia coliEscherichia coli ProteinsProteolysisProteomeAmino AcidsBacterial ProteinsCarbonGene Expression Regulation, BacterialSigma FactorAmino AcidsBacterial ProteinsCarbonEscherichia coli ProteinsProteomeSigma Factorsigma factor KatF protein, Bacteriaproteolysisproteome remodelingresource allocationstarvation responsestationary phase
Identifiers
PMID42879477
PMCPMC13684143
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