Evidence map›Paper›PMID 42879475›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

The impact of modulator therapy on the

Morgana Letizia, Lauren E Whiteley, Frances L Diggle, Angela N Davis, Sarah J Morgan, Brenda Grogan, John Baugh, Edward F McKone, Pradeep K Singh, Marvin Whiteley

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The impact of modulator therapy on theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Morgana LetiziaSchool of Biological Sciences and Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-4795-6259
Lauren E WhiteleySchool of Biological Sciences and Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, GA 30332.
Frances L DiggleSchool of Biological Sciences and Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, GA 30332.
Angela N DavisSchool of Biological Sciences and Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0009-0004-9242-689X
Sarah J MorganDepartment of Microbiology, University of Washington School of Medicine, Seattle, WA 98195.
Brenda GroganNational Referral Center for Adult Cystic Fibrosis, National Referral Center for Adult Cystic Fibrosis, St. Vincent's University Hospital, Dublin D04 T6F4, Ireland.
John BaughUniversity College Dublin School of Medicine, Dublin D04 C7X2, Ireland.
Edward F McKoneNational Referral Center for Adult Cystic Fibrosis, National Referral Center for Adult Cystic Fibrosis, St. Vincent's University Hospital, Dublin D04 T6F4, Ireland.
Pradeep K SinghDepartment of Microbiology, University of Washington School of Medicine, Seattle, WA 98195.
Marvin WhiteleySchool of Biological Sciences and Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-4933-9983

Funding

Cystic Fibrosis Foundation (CFF) LETIZI24G0-BASBAUMCystic Fibrosis Foundation (CFF) WHITEL20A0Cystic Fibrosis Foundation (CFF) WHITEL22G0
6 · The paper itself

Abstract

Chronic lung infection with

Indexed as

Cystic FibrosisLungPseudomonas aeruginosaPseudomonas InfectionsTranscriptomeAminophenolsBenzodioxolesCystic Fibrosis Transmembrane Conductance RegulatorGene Expression Regulation, BacterialHumansIndolesPyrrolesQuinolonesSputumAminophenolsBenzodioxolesCystic Fibrosis Transmembrane Conductance RegulatorIndolesivacaftorPyrrolesQuinolonestezacaftorCF modulatorscystic fibrosismodel systemPseudomonas aeruginosatranscriptomics

Identifiers

PMID42879475
PMCPMC13684289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.