Trial reportPloS one2026
Quality of recovery after arthroscopic meniscectomy with remimazolam or propofol anesthesia: A randomized controlled trial.
Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnesthetic technique may influence postoperative quality of recovery (QoR). Remimazolam may offer hemodynamic stability and favorable early recovery characteristics, but its effect on patient-reported QoR compared with propofol remains unclear. This is particularly relevant in minor orthopedic surgery, where QoR is a principal outcome. This randomized controlled trial compared postoperative QoR between propofol-based and remimazolam-based total intravenous anesthesia (TIVA) using the QoR-40 questionnaire. MATERIALS AND
methodsEighty adult patients undergoing elective arthroscopic meniscectomy were randomly assigned to propofol-based or remimazolam-based TIVA; 71 patients completed the QoR-40 questionnaire and were included in the final analysis (36 in the Propofol group, 35 in the Remimazolam group). The primary outcome was the global QoR-40 score on postoperative day (POD) 1. Secondary outcomes included intraoperative hemodynamic variables, anesthetic and analgesic requirements, postoperative recovery profiles, pain scores, and postoperative nausea and vomiting.
resultsGlobal QoR-40 scores on POD 1 did not differ significantly between the Propofol and Remimazolam groups (166.1 ± 16.8 vs. 170.6 ± 13.6; mean difference -4.5, 95% CI -11.8 to 2.7; P = 0.218). In an exploratory analysis, the emotional-state domain scores were higher in the Remimazolam group (37.0 ± 4.3 vs. 39.2 ± 2.5; mean difference -2.2, 95% CI -3.9 to -0.6; P = 0.009). The Remimazolam group had a longer time to full alertness (18 [15-24] vs. 37 [31-45] min; P < 0.001) and longer post-anesthesia care unit stay (30 [30-39] vs. 38 [30-50] min; P = 0.008). Intraoperative hypotension requiring ephedrine occurred more frequently in the Propofol group (44.4% vs. 17.1%; P = 0.013).
conclusionsGlobal QoR-40 scores on POD 1 did not differ significantly between propofol-based and remimazolam-based TIVA in adults undergoing elective arthroscopic meniscectomy, although remimazolam was associated with greater intraoperative hemodynamic stability at the cost of slower return to full alertness.
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