ReviewDialogues in clinical neuroscience2027
Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.
Review in Dialogues in clinical neuroscience, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Based on a synthesis of recent advances, this review elucidates the distinct yet synergistic roles of non-rapid eye movement (NREM) and rapid eye movement (REM) sleep in memory consolidation. During NREM sleep, cortical slow oscillations (SOs) establish a temporal framework by alternating between UP and DOWN states, facilitating cross-regional communication. SOs phase-couple with thalamic spindles to coordinate hippocampal sharp-wave ripples (SWRs), thereby driving the reactivation and transfer of labile hippocampal memories to neocortical networks for long-term storage. Concurrent synaptic homeostasis optimises network efficiency through global downscaling while selectively strengthening memory-relevant connections. In REM sleep, theta oscillations synchronise limbic-prefrontal-hippocampal circuits, and ponto-geniculo-occipital (PGO) waves further integrate emotional and procedural memories. The cholinergically dominant, monoamine-depleted neurochemical milieu of REM sleep promotes dendritic spine remodelling and sparse neuronal reactivation, enabling affective decoupling and synaptic refinement. Despite progress, key challenges remain in understanding cross-frequency oscillatory coupling among slow oscillations, spindles, ripples and REM-specific rhythms, glial contributions and clinical translation. Future integration of high-density electrophysiology with computational approaches may yield mechanistic models and clinically relevant biomarkers for sleep-based cognitive monitoring and intervention.
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