Evidence map›Paper›PMID 42879303›Full record

Trial reportGut microbes2026

The impact of prophylactic azithromycin on the developing preterm gut microbiome and resistome.

Sinead Ahearn-Ford, Ali Aboklaish, Gregory R Young, John Lowe, Andrea C Masi, David Gallacher, Julian R Marchesi, Janet E Berrington, Sailesh Kotecha, Christopher J Stewart

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sinead Ahearn-FordTranslational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.ORCID 0000-0001-5979-9636
Ali AboklaishDepartment of Child Health, Cardiff University School of Medicine, Cardiff, UK.ORCID 0000-0002-6426-8757
Gregory R YoungTranslational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.ORCID 0000-0001-5342-1421
John LoweCentre For Trials Research, Cardiff University, Cardiff, UK.ORCID 0000-0003-4772-1879
Andrea C MasiTranslational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.ORCID 0000-0002-4714-9174
David GallacherNeonatal Unit, UHW, Cardiff, UK.ORCID 0000-0003-2548-3056
Julian R MarchesiDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-7994-5239
Janet E BerringtonTranslational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.ORCID 0000-0002-6185-2843
Sailesh KotechaNeonatal Unit, UHW, Cardiff, UK.ORCID 0000-0003-3535-7627
Christopher J StewartTranslational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.ORCID 0000-0002-6033-338X

Funding

Wellcome Trust
6 · The paper itself

Abstract

Early-life antibiotic exposure can profoundly impact the developing preterm gut microbiome and resistome, with short- and long-term consequences for health. In a large multi-center (

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisAzithromycinBacteriaGastrointestinal MicrobiomeInfant, PrematureDouble-Blind MethodDrug Resistance, BacterialFemaleHumansInfant, NewbornMaleProbioticsRNA, Ribosomal, 16SAnti-Bacterial AgentsAzithromycinRNA, Ribosomal, 16Santibiotic resistanceazithromycinbroad spectrum antibioticsbronchopulmonary dysplasiaearly-life antibiotic exposureinfant gut microbiomeMicrobiomeplacebo-controlled trialpreterm infantsprobiotics

Identifiers

PMID42879303
PMCPMC13679317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.