Evidence map›Paper›PMID 42879114›Full record

ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026

MACC1 in colorectal cancer: a claim-level evidence audit from metastasis driver to proposed microenvironmental regulator.

Rui Yang, Ruilan Deng, Hao Lin, Dongyang Huang, Ting Su, Xuhong Song, Bin Liang, Lingzhu Xie

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rui Yang *Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, China.
Ruilan Deng *Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, China.
Hao LinDepartment of Gastroenterology, Shantou Central Hospital, Shantou, 515041, China.
Dongyang HuangKey Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, China.
Ting SuKey Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, China.
Xuhong SongKey Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, China.
Bin LiangKey Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, China.
Lingzhu XieKey Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, China. lzxie@stu.edu.cn.ORCID http://orcid.org/0000-0002-3591-5767

Funding

Natural Science Foundation of Guangdong Province 2023A1515010434
6 · The paper itself

Abstract

Metastasis-associated in colon cancer 1 (MACC1) is an established regulator of colorectal cancer (CRC) progression and metastatic competence, but its proposed role in the tumour microenvironment is less certain. We performed a critical claim-level audit of original studies, classifying evidence by cancer-type match, manipulated cellular compartment, direct MACC1 perturbation, functional recipient cell endpoint, and immune context. The audit identifies convergent CRC evidence for tumour cell-intrinsic functions and inflammatory regulation of tumour cell MACC1. It also supports MACC1-dependent extracellular vesicle communication between CRC cells. By contrast, direct immune or stromal causality in CRC is not yet demonstrated: the available macrophage result is pharmacologically conditioned, functional immune and fibroblast mechanisms come from other cancers, and CRC immune associations are mainly computational. We define the conclusions permitted by each evidence class, specify clinical guardrails for prognostic and treatment-predictive claims, and propose two experiments that could establish or falsify cell-specific microenvironmental functions.

Indexed as

Colorectal cancerEvidence boundariesExtracellular vesiclesMACC1MetastasisTumour microenvironment

Identifiers

PMID42879114

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.