Evidence map›Paper›PMID 42879023›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2027

Genetically Engineered Mouse Model in Ewing Sarcoma.

Miwa Tanaka, Takuro Nakamura

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Miwa TanakaDepartment of Pharmacology and Therapeutics, Research Institute, National Cancer Center Japan, Tokyo, Japan.
Takuro NakamuraDepartment of Experimental Pathology, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan. takuron@tokyo-med.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modeling Ewing sarcoma is challenging, since overexpression of EWSR1::FLI1 induces apoptosis and is not sufficient for tumor induction. It is therefore important to obtain the cell-of-origin of Ewing sarcoma that is tolerant of EWSR1::FLI1 expression. Here we describe the generation of the EWSR1::FLI1-expressing mouse model for Ewing sarcoma by selecting embryonic chondrogenic progenitor, eSZ cells that contain Ewing sarcoma precursors.

Indexed as

Bone NeoplasmsDisease Models, AnimalGenetic EngineeringSarcoma, EwingAnimalsHumansMiceMice, TransgenicOncogene Proteins, FusionProto-Oncogene Protein c-fli-1RetroviridaeRNA-Binding Protein EWSOncogene Proteins, FusionProto-Oncogene Protein c-fli-1RNA-Binding Protein EWSEmbryonic superficial zoneEwing sarcomaEWSR1::FLI1Mouse modelRetrovirus-mediated gene transfer

Identifiers

PMID42879023

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.