Evidence map›Paper›PMID 42878942›Full record

ArticleJournal of molecular histology2026

Heparin-binding protein aggravates sepsis-induced acute lung injury by inhibiting the PERK-Nrf2-HO-1 signaling pathway.

LiFen Qian, QiuMin Zhao, Yan Wang, JingWen Zhang, Jie Wang, Wei Lin, HaiPing Jiang, Yue Cui, ShiYan Ji

Abstract read
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Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

LiFen Qian *Department of Pediatric Internal Medicine, Changzhou Children's Hospital of Nantong University, Changzhou City, 213003, Jiangsu Province, China.
QiuMin Zhao *Department of Laboratory Medicine, Changzhou Children's Hospital of Nantong University, Changzhou City, 213003, Jiangsu Province, China.
Yan WangDepartment of Laboratory Medicine, Changzhou Children's Hospital of Nantong University, Changzhou City, 213003, Jiangsu Province, China.
JingWen ZhangDepartment of Laboratory Medicine, Changzhou Children's Hospital of Nantong University, Changzhou City, 213003, Jiangsu Province, China.
Jie WangDepartment of Laboratory Medicine, Changzhou Children's Hospital of Nantong University, Changzhou City, 213003, Jiangsu Province, China.
Wei LinDepartment of Laboratory Medicine, Changzhou Children's Hospital of Nantong University, Changzhou City, 213003, Jiangsu Province, China.
HaiPing JiangDepartment of Laboratory Medicine, Changzhou Children's Hospital of Nantong University, Changzhou City, 213003, Jiangsu Province, China.
Yue CuiDepartment of Laboratory Medicine, Changzhou Children's Hospital of Nantong University, Changzhou City, 213003, Jiangsu Province, China.
ShiYan Ji *Department of Children's Health Research Center, Changzhou Children's Hospital of Nantong University, No.958, Zhongwu Avenue, Diaozhuang Street, Tianning District, Changzhou City, 213003, Jiangsu Province, China. Shiyanji1206@outlook.com.

Funding

Changzhou Bureau of Science and Technology Research Project project No. CJ20241030Changzhou Municipal Health Commission Scientific Research Project project No.QN202421
6 · The paper itself

Abstract

Sepsis, a systemic inflammatory response disorder triggered by infection, often leads to multiple organ dysfunction syndrome. Sepsis-induced acute lung injury (SI-ALI) is among the most common complications. Heparin-binding protein (HBP), a major inflammatory mediator, has been demonstrated to induce vascular permeability and inflammation. Nevertheless, the mechanism by which HBP functions in sepsis-induced lung injury remains unclear. This study aimed to explore the role of HBP in sepsis-induced lung injury. A sepsis mouse model was established via cecal ligation and puncture (CLP), followed by HBP blockade using heparin. Serum inflammatory cytokine levels were measured by enzyme-linked immunosorbent assay (ELISA). Neutrophil infiltration was assessed by myeloperoxidase (MPO) activity. Lung tissue pathology was evaluated using hematoxylin-eosin (H&E) and Masson staining. Levels of ferrous iron (Fe

Indexed as

Acute Lung InjuryCarrier ProteinseIF-2 KinaseHeme Oxygenase-1Membrane ProteinsNF-E2-Related Factor 2SepsisSignal TransductionAnimalsDisease Models, AnimalLungMaleMiceMice, Inbred C57BLReactive Oxygen SpeciesCarrier ProteinseIF-2 KinaseHeme Oxygenase-1Membrane ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2Reactive Oxygen SpeciesFerroptosisHeparin-binding proteinLung injuryPERK-Nrf2-HO-1 signaling pathwaySepsis

Identifiers

PMID42878942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.