Evidence map›Paper›PMID 42878902›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

From incidental cerebellar atrophy to progressive motor syndrome: a case within the spectrum of ATXN2-associated neurodegeneration.

Xin Huang, Yan Ma, Xinran Ma, Kailin Xia, Dongsheng Fan

Abstract readCase ReportsLetter
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xin HuangDepartment of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.ORCID 0000-0002-1764-4537
Yan MaDepartment of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.
Xinran MaDepartment of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.
Kailin XiaDepartment of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.
Dongsheng FanDepartment of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China. dsfan@sina.com.

Funding

PUTH Clinical Key Projects BYSYZD2024007the special fund of the National Clinical Key Specialty Construction Program, P. R. China (2024) the special fund of the National Clinical Key Specialty Construction Program, P. R. China (2024)
6 · The paper itself

Abstract

backgroundIncreasing evidence suggests that ATXN2-related disorders represent a clinical spectrum with variable presentations. CASE PRESENTATION: We report a 70-year-old Chinese man carrying an ATXN2 allele with 34 CAG repeats (20/34 repeats). Cerebellar atrophy was incidentally noted on magnetic resonance imaging (MRI) more than ten years before symptom onset. He later developed bradykinesia and rigidity. After rapid weight loss, he developed a rapidly progressive motor syndrome with clinical upper and lower motor neuron features, followed by type II respiratory failure requiring noninvasive ventilation.

conclusionsThese findings support the notion that ATXN2-associated neurodegeneration may represent a clinical continuum.

Indexed as

Ataxin-2CerebellumNeurodegenerative DiseasesAgedAtrophyDisease ProgressionHumansMagnetic Resonance ImagingMaleAtaxin-2ATXN2 protein, humanATXN2CAG repeat expansionCerebellar atrophyMotor syndrome

Identifiers

PMID42878902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.