Evidence map›Paper›PMID 42878876›Full record

ReviewCell and tissue research2026

Cells for blastema formation: Lessons from the annelid regenerative model.

Toshiyuki Fujita, Shinji Yamaguchi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cell and tissue research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Toshiyuki FujitaDepartment of Biological Sciences, Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo, Japan.
Shinji YamaguchiDepartment of Biological Sciences, Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo, Japan. shinji-y@pharm.teikyo-u.ac.jp.

Funding

Japan Society for the Promotion of Science 25K09943
6 · The paper itself

Abstract

Regeneration in many animals involves the formation of blastema, a mass of undifferentiated, proliferating cells. The origin of blastema cells is a key question in regenerative biology. Two major theories are: (1) the migration of lineage-restricted stem cells, supported by studies in salamanders and planaria, and (2) the dedifferentiation of somatic cells at the injury site, which has been observed in newts, mice, zebrafish, and crickets. Because different models support these theories, the generality of either mechanism is unclear. To address this, these theories should be investigated in a wider range of regenerative model animals. To this end, Fujita et al. (2024) studied the regenerative annelid Enchytraeus japonensis and discovered that soxC-expressing cells are crucial for blastema formation. In this review, we introduce an annelid model system for regeneration biology and the roles of soxC-expressing cells during blastema formation.

Indexed as

AnnelidaModels, BiologicalRegenerationAnimalsStem CellsAnnelidBlastemaCrosstalkE. japonensisRegenerationSoxCStem cellWnt

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.