Evidence map›Paper›PMID 42878707›Full record

ArticleJournal of human immunity2027

Hematopoietic cell transplantation using treosulfan-based conditioning for IL-10 receptor deficiency.

Madhavi Lakkaraja, Erica G Schmitt, Amika K Sood, Karin Chen, Arunkumar J Modi, James W Verbsky, Troy Torgerson, Ghassan Wahbeh, Aleksandra Petrovic, K Scott Baker and 2 more

Abstract read
In one paragraph

Article in Journal of human immunity, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Madhavi Lakkaraja *Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-8410-8662
Erica G Schmitt *Department of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-8878-0619
Amika K SoodDepartment of Medicine, Division of Allergy/Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0009-0000-3641-1475
Karin ChenDepartment of Pediatrics, Division of Immunology, University of Washington School of Medicine, and Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0001-5593-436X
Arunkumar J ModiDivision of Bone Marrow Transplant and Cellular Therapies, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0002-9323-8979
James W VerbskyDepartment of Pediatrics, Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-6682-1002
Troy TorgersonAllen Institute for Immunology , Seattle, WA, USA.ORCID 0000-0003-3489-5036
Ghassan WahbehDepartment of Pediatrics, Division of Gastroenterology, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0009-0003-1821-7689
Aleksandra PetrovicDepartment of Pediatrics, Division of Hematology-Oncology/BMT, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0002-3303-7032
K Scott BakerClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-3377-1648
Megan A CooperDepartment of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5696-172X
Lauri M BurroughsClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-1124-4740

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
American Society of HematologyCancer and Blood Disorders CenterChildren's Discovery Institute of Washington University's Center for Pediatric ImmunologyNCI NIH HHSNIH HHS 1K08AI182483NIH HHS P30CA015704St. Louis Children's Hospital
6 · The paper itself

Abstract

IL-10 receptor deficiency is a life-threatening inborn error of immunity associated with early-onset inflammatory bowel disease. Hematopoietic cell transplantation (HCT) using treosulfan-based conditioning resulted in excellent survival with full donor engraftment. Importantly, anakinra effectively served as a bridge to HCT.

Identifiers

PMID42878707
PMCPMC13671123

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.