ArticleInvestigative ophthalmology & visual science2026
The A53T Parkinson's Disease Mouse Model Shows Abnormal Outer Retinal OCT Metabolic Biomarker Patterns.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The purpose of this study was to test for abnormal optical coherence tomography (OCT) metabolic biomarker patterns in the A53T Parkinson's disease model, which accumulates α-synuclein in photoreceptor inner segments before overt motor symptoms. Methods: Four-to-6-month-old transgenic A53T homozygous mice and B6C3H wild-type (WT) littermate controls were evaluated using 2 OCT metabolic biomarkers. The first was the external limiting membrane (ELM) to retinal pigment epithelium (RPE) thickness, a proxy for subretinal space acidification and retinoid deficiency. The second biomarker was the sub-ELM hyper-reflective band profile shape minor:major aspect ratio, a proxy for mitochondrial configuration within photoreceptor inner segments. We also tested for outer nuclear layer (ONL) thinning, OCT metabolic biomarker sensitivity to light-dark conditions, and nicotinamide nucleotide transhydrogenase (Nnt) expression. Results: A53T mice showed inferior and superior subnormal ELM-RPE thickness, and a supranormal sub-ELM hyper-reflective band profile shape aspect ratio in the inferior but not the superior retina. Central retinal ONL thickness was unremarkable between groups. Compared to light, dark-adaptation evoked contraction in ELM-RPE thickness and an increase in sub-ELM hyper-reflective band profile shape aspect ratio in both cohorts. In addition, B6C3H control mice expressed functional Nnt. Conclusions: The abnormal OCT metabolic biomarker patterns raise the possibility of central outer retinal dysmetabolism in A53T mice, despite normal ONL thickness. Light-dark results show that ELM-RPE contraction can be caused by increased metabolic demand in the A53T mouse model.
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