ArticleArchives of endocrinology and metabolism2026
Tetraethylammonium-Sensitive ventricular repolarization in diabetic rat myocardium: effects of rosiglitazone.
Article in Archives of endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo examine ventricular action-potential responses to tetraethylammonium (TEA), a non-selective potassium-channel blocker, in streptozotocin-induced diabetic rats and determine whether rosiglitazone modifies these responses. MATERIALS AND
methodsMale Wistar rats were assigned to Control (C), Control plus Rosiglitazone (C+RSG), Diabetic (D), or Diabetic plus Rosiglitazone (D+RSG) groups. Diabetes was induced with streptozotocin (45 mg/kg, intravenous). Resting membrane potential (RMP), action potential amplitude (APA), and half-repolarization time (½RT) were recorded from isolated left ventricular papillary muscles before and after TEA administration (2 mmol/L).
resultsAt week 8, blood glucose was 563 ± 29 mg/dL in diabetic rats and 98 ± 6 mg/dL in controls (p < 0.001). Rosiglitazone reduced the diabetic value to 336 ± 25 mg/dL (p < 0.05 vs. D). TEA increased ½RT from 18 ± 1 to 38 ± 2 ms in controls (+20 ms) and from 60 ± 3 to 65 ± 3 ms in diabetic myocardium (+5 ms). Diabetic preparations had higher post-TEA ½RT because repolarization was prolonged at baseline; however, the absolute TEA-associated increment was smaller than in controls. TEA also increased APA in untreated control and diabetic preparations.
conclusionDiabetes was associated with marked baseline prolongation of ventricular repolarization. The smaller absolute ½RT increment in diabetic myocardium does not support enhanced TEA responsiveness. Because TEA is non-selective, the findings reflect an integrated response to TEA-sensitive potassium conductances rather than dysfunction of a specific current subtype. Rosiglitazone modified selected electrophysiological responses without normalizing diabetic repolarization.
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