ArticleImmunity, inflammation and disease2026
Dynamic Shifts in Lymphocyte Subsets During the Menopausal Transition and Sexual Dimorphism in Immunosenescence.
Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundImmunosenescence demonstrates marked sexual dimorphism, yet the dynamic changes in lymphocyte subsets across the female menopausal transition are poorly defined. This study characterized these age- and sex-related immune variations in a large Chinese cohort.
methodsIn this cross-sectional study, we analyzed 4209 healthy adults using flow cytometry to quantify lymphocyte subsets and PD-1 expression. Females were stratified by age and reproductive stage. Sex comparisons were performed after propensity score age-matching.
resultsAnalysis of the female cohort revealed dynamic immune shifts during the menopausal transition, characterized by a "scissor-like" pattern: CD3
conclusionThese findings suggest that the perimenopausal period represents a key phase of immune remodeling in women, and support the integration of sex and reproductive stage into future immunosenescence research and clinical strategies.
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