Evidence map›Paper›PMID 42878270›Full record

ArticleChemistry & biodiversity2026

Impact of Plant Pre-Processing on the Chemical Profile of Psidium guajava L. (Myrtaceae) Essential Oil and Evaluation of Its Bioactive Potential.

Tarsila da C Silva, Ari Sérgio de O Lemos, Caio Juan S Fortes, Débora N Eiriz, Elaine S Coimbra, Lucas de A Carvalho, Luciana M Chedier, Lucas M Duarte, Núbia B Andrade, Rodrigo L Fabri and 2 more

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tarsila da C SilvaDepartment of Organic Chemistry, Federal Fluminense University (UFF), Niterói, Rio de Janeiro, Brazil.ORCID https://orcid.org/0009-0007-1062-8407
Ari Sérgio de O LemosDepartment of Organic Chemistry, Federal Fluminense University (UFF), Niterói, Rio de Janeiro, Brazil.
Caio Juan S FortesLaboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.
Débora N EirizAnalytical Separations and Chemometrics Research Group, Federal Fluminense University (UFF), Niterói, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-1123-1608
Elaine S CoimbraDepartment of Parasitology, Microbiology, and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-1005-278X
Lucas de A CarvalhoLaboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-8398-8189
Luciana M ChedierDepartment of Botany, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-8212-8056
Lucas M DuarteAnalytical Separations and Chemometrics Research Group, Federal Fluminense University (UFF), Niterói, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-5509-3513
Núbia B AndradeLaboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.ORCID https://orcid.org/0009-0004-1481-2859
Rodrigo L FabriLaboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-0167-2277
Selma R de PaivaDepartment of General Biology, Institute of Biology, Federal Fluminense University (UFF), Niterói, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-8295-7011
Alessandra L ValverdeDepartment of Organic Chemistry, Federal Fluminense University (UFF), Niterói, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-1250-1051

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de JaneiroUniversidade Federal de Juiz de ForaUniversidade Federal Fluminense
6 · The paper itself

Abstract

The chemical composition and bioactivity of essential oils depend not only on agronomic and environmental factors but also on the pre-processing of the plant material, a step that is rarely evaluated. Leaf essential oils of Psidium guajava L. were obtained by hydrodistillation from fresh or previously frozen leaves fragmented manually or mechanically, and assessed for GC-MS composition, cytotoxicity and biological activities. Fresh leaves ground in a mixer (EOFH-M) gave a sesquiterpene-rich profile dominated by β-caryophyllene and α-humulene, along with the best cell-viability profile in L929 fibroblasts and BALB/c macrophages. EOFH-M reduced nitric oxide and intracellular reactive oxygen species and showed a fungicidal effect against Candida albicans and the emerging and resistant microorganism Candida auris, whereas isolated β-caryophyllene was fungistatic. Leaf pre-processing therefore substantially influences the composition, safety and antifungal potential of P. guajava essential oil.

Indexed as

Antifungal AgentsOils, VolatilePsidiumAnimalsCandidaCandida albicansCell SurvivalGas Chromatography-Mass SpectrometryMacrophagesMiceMice, Inbred BALB CMicrobial Sensitivity TestsNitric OxidePlant LeavesPolycyclic SesquiterpenesReactive Oxygen SpeciesAntifungal AgentscaryophylleneNitric OxideOils, VolatilePolycyclic SesquiterpenesReactive Oxygen SpeciesSesquiterpenesantifungal activityanti‐inflammatory activityCandida aurisPsidium guajavaβ‐caryophyllene

Identifiers

PMID42878270
PMCPMC13670397

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.