Evidence map›Paper›PMID 42878194›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Attention-deficit/hyperactivity disorder polygenic risk score and incidence of cognitive impairment in older adults: A prospective multicohort study.

Douglas Teixeira Leffa, Guilherme Bauer-Negrini, Livia Amaral, Bruna Bellaver, Pamela C L Ferreira, Guilherme Povala, Firoza Z Lussier, João Pedro Ferrari-Souza, Ann D Cohen, Dana L Tudorascu and 5 more

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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Douglas Teixeira LeffaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4890-8451
Guilherme Bauer-NegriniDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Livia AmaralDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bruna BellaverDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Pamela C L FerreiraDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Guilherme PovalaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Firoza Z LussierDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
João Pedro Ferrari-SouzaNeuroscience Unit, Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil.
Ann D CohenDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Dana L TudorascuDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Samuele CorteseDevelopmental EPI (Evidence synthesis, Prediction, Implementation) Lab, Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
Luis Augusto RohdeADHD Outpatient Program & Development Psychiatry Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Brooke S G MolinaDepartments of Psychiatry, Psychology, Pediatrics, Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Derek ArcherVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Tharick A PascoalDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Longitudinal multicenter head-to-head harmonization of tau PET tracersR01AG073267 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAKER, SUZANNE L, PASCOAL, THARICK · 2021 to 2025
$41.1M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Head-to-head comparisons of high-performance plasma phospho-tau epitopes for the detection of Alzheimer's diseaseR01AG075336 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tharick Pascoal · 2022 to 2026
$3.7M
NIA NIH HHS K01-073584NIA NIH HHS R01AG073267NIA NIH HHS R01AG075336NIA NIH HHS U24AG074855
6 · The paper itself

Abstract

introductionPreliminary evidence suggests a link between attention-deficit/hyperactivity disorder (ADHD) and later-life cognitive impairment. Whether genetic risk for ADHD, estimated using an ADHD polygenic risk score (ADHD-PRS), is associated with incident cognitive impairment (mild cognitive impairment or Alzheimer's disease dementia) remains unknown.

methodsWe analyzed 7761 cognitively unimpaired (CU) older adults with whole-genome sequencing from eight cohorts participating in the Alzheimer's Disease Sequencing Project (ADSP).

resultsDuring follow-up, 1347 participants developed cognitive impairment. Ten-year cumulative incidence was 33.8% in the highest ADHD-PRS tertile versus 23.4% in the lowest. In Cox models, higher ADHD-PRS remained associated with greater risk of cognitive impairment after adjustment for education, apolipoprotein E (APOE) ε4 status, or vascular risk. PRSs for other major psychiatric disorders were not associated with cognitive impairment in the same analytic framework. In a subsample with biomarker data, the association was not modified by baseline amyloid-β status. DISCUSSION: These findings support ADHD-PRS as a novel correlate of cognitive impairment and vulnerability in aging.

Indexed as

Attention Deficit Disorder with HyperactivityCognitive DysfunctionAgedFemaleGenetic Risk ScoreHumansIncidenceMaleProspective StudiesRisk Factorsalzheimer's diseasealzheimer's disease sequencing projectamyloid betaattention‐deficit/hyperactivity disordercognitive agingcognitive impairmentdementiamild cognitive impairmentolder adultspolygenic risk score

Identifiers

PMID42878194
PMCPMC13670426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.