ArticleACG case reports journal2026
Invasive Cryptococcal Meningitis: A Sequelae of Primary Intestinal Lymphangiectasia.
Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Primary intestinal lymphangiectasia (PIL) is a protein-losing enteropathy causing enteric loss of albumin, immunoglobulins, and lymphocytes. Untreated or inadequately monitored PIL may result in secondary immunodeficiency and opportunistic infections. We report a 30-year-old man with a childhood diagnosis of PIL who developed cryptococcal meningoencephalitis. Evaluation revealed secondary immunodeficiency with lymphopenia and hypogammaglobulinemia which was attributed to ongoing protein-losing enteropathy despite absence of gastrointestinal symptoms, supported by hypoalbuminemia and fat-soluble vitamin deficiencies. This is the third reported case of PIL-associated cryptococcal meningitis and the first in a patient with a previously established diagnosis, highlighting consequences of lapsed subspecialty follow-up in adulthood.
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