Evidence map›Paper›PMID 42877835›Full record

ArticleBalkan journal of medical genetics : BJMG2026

Rare Double Reciprocal Translocations in a Man with Reproductive Success and Recurrent Pregnancy Loss.

F E Aouni, F Smaili, K Zerrouki, J Ahmidi, S Meziane, K Ahmidouch, A Chyadmi, A El Ammari, H Saadi, M Tajir

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Balkan journal of medical genetics : BJMG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

F E AouniMedical Genetics Laboratory, Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.
F SmailiMedical Genetics Laboratory, Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.
K ZerroukiMedical Genetics Laboratory, Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.
J AhmidiMedical Genetics Laboratory, Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.
S MezianeMedical Genetics Laboratory, Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.
K AhmidouchMedical Genetics Laboratory, Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.
A ChyadmiMedical Genetics Laboratory, Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.
A El AmmariMedical Genetics Laboratory, Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.
H SaadiFaculty of Medicine and Pharmacy, Mohammed Premier University, Oujda, Morocco.
M TajirMedical Genetics Laboratory, Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Double reciprocal translocations represent an extremely rare cytogenetic entity. Carriers have a significantly increased risk of producing unbalanced gametes during meiosis, which can lead to adverse reproductive outcomes such as miscarriages or offspring with congenital anomalies. Despite the high reproductive risk, they can give birth either to a balanced translocation carrier with a normal phenotype (similar to the parents) or to a chromosomally normal completely healthy infant, resulting only from alternate 2:2 segregation. Here, we report an exceptional case of double-balanced reciprocal translocations involving four chromosomes (1, 3, 15 and 18) in a phenotypically normal male partner. The couple was investigated due to a history of recurrent pregnancy loss, having already had one phenotypically normal child. The aim of this report is to analyze the cytogenetic finding, predict the possible meiotic segregation outcomes, and discuss the implications in genetic counseling.

Indexed as

Alternate segregationDouble reciprocal translocationsGenetic counsellingKaryotyping analysisphenotypically normal childRecurrent pregnancy loss

Identifiers

PMID42877835
PMCPMC13667936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.