ArticleHealth science reports2026
Comparison of Metronidazole Gel and Povidone‑Iodine for Vaginal Preparation in Preventing Post‑Cesarean Infection‑Related Morbidity: A Three‑Group Randomized Controlled Trial.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background and Aims: Despite routine prophylactic antibiotics, post-cesarean infectious morbidity remains a major challenge. Preoperative vaginal preparation can reduce vaginal microbial load, but direct comparisons are scarce. This study compared metronidazole gel versus povidone-iodine for preventing post-cesarean infection‑related complications. Methods: This three‑arm randomized controlled trial was conducted at Fatemieh Hospital, Hamadan, Iran, from December 2025 to May 2026. A total of 201 women scheduled for elective cesarean delivery were randomized to metronidazole gel 0.75%, povidone-iodine 10%, and control ( Results: The composite infectious morbidity was significantly lower in the metronidazole group (6/67, 8.96%) compared to controls (21/67, 31.34%) (risk difference: 22.4%; 95% CI: 9.5%-35.3%; Conclusions: Metronidazole gel significantly reduced composite infectious morbidity compared with no vaginal preparation, an effect that remained significant after adjustment for multiple comparisons. While individual outcomes showed clinically meaningful reductions, statistical significance was not maintained after Bonferroni correction. Metronidazole gel may be a promising option for vaginal preparation, particularly in high-risk settings. Trial Registration: IRCT20251227068466N1.
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